Biomarkers of Kidney Injury in Very-low-birth-weight Preterm Infants: Influence of Maternal and Neonatal Factors

Overview

Journal In Vivo

Specialty Oncology

Date 2020 May 2

PMID 32354927

Citations 6

Authors

Irene Capelli

Francesca Vitali

Fulvia Zappulo

Silvia Martini

Chiara Donadei

Maria Cappuccilli

Luca Leonardi

Anna Girardi

Valeria Aiello

Silvia Galletti

Giacomo Faldella

Elisabetta Poluzzi

Fabrizio De Ponti

La Manna Gaetano

Affiliations

Soon will be listed here.

Abstract

Background/aim: Acute kidney injury is an important cause of mortality in very-low-birth-weight (VLBW) preterm infants. As in the general population, the detection of renal damage cannot rely on the measurement of serum creatinine, since it has been demonstrated to be a weak predictor and a delayed indicator of kidney function deterioration. However, several candidate biomarkers have failed to prove sufficient specificity and sensitivity for a routine clinical use because of the poor awareness of their biological role. This study was aimed to investigate the impact of different maternal and neonatal conditions on several renal biomarkers in VLBW preterm infants during the first week of life.

Patients And Methods: Preterm infants<32 weeks' gestation and <1500g were enrolled. We measured urinary biomarkers kidney injury molecule 1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, epidermal growth factor (EGF) and osteopontin (OPN) on the 1, 3, and 7 day after birth.

Results: Thirty-tree infants were included. The multivariate analysis showed a significant association between gestational age, the presence of patent ductus arteriosus, antenatal maternal hypertension and the levels of urinary biomarkers.

Conclusion: There is a possible relation between early biomarkers of renal injury and antenatal, perinatal and post-natal characteristics in VLBW preterm infants during the first week of life.

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References

Lavery A, Meinzen-Derr J, Anderson E, Ma Q, Bennett M, Devarajan P . Urinary NGAL in premature infants. Pediatr Res. 2008; 64(4):423-8. DOI: 10.1203/PDR.0b013e318181b3b2. View

Kastl J . Renal function in the fetus and neonate - the creatinine enigma. Semin Fetal Neonatal Med. 2017; 22(2):83-89. DOI: 10.1016/j.siny.2016.12.002. View

Patel M, Sachan R, Gangwar R, Sachan P, Natu S . Correlation of serum neutrophil gelatinase-associated lipocalin with acute kidney injury in hypertensive disorders of pregnancy. Int J Nephrol Renovasc Dis. 2013; 6:181-6. PMC: 3794962. DOI: 10.2147/IJNRD.S45523. View

Meisner A, Kerr K, Thiessen-Philbrook H, Coca S, Parikh C . Methodological issues in current practice may lead to bias in the development of biomarker combinations for predicting acute kidney injury. Kidney Int. 2015; 89(2):429-38. PMC: 4805513. DOI: 10.1038/ki.2015.283. View

Tosse V, Pillekamp F, Verde P, Hadzik B, Sabir H, Mayatepek E . Urinary NT-proBNP, NGAL, and H-FABP may predict hemodynamic relevance of patent ductus arteriosus in very low birth weight infants. Neonatology. 2012; 101(4):260-6. DOI: 10.1159/000334826. View

Saeidi B, Koralkar R, Griffin R, Halloran B, Ambalavanan N, Askenazi D . Impact of gestational age, sex, and postnatal age on urine biomarkers in premature neonates. Pediatr Nephrol. 2015; 30(11):2037-44. PMC: 4581905. DOI: 10.1007/s00467-015-3129-z. View

. ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia. Obstet Gynecol. 2018; 133(1):1. DOI: 10.1097/AOG.0000000000003018. View

Sellmer A, Bech B, Bjerre J, Schmidt M, Hjortdal V, Esberg G . Urinary Neutrophil Gelatinase-associated Lipocalin in the evaluation of Patent Ductus Arteriosus and AKI in Very Preterm Neonates: a cohort study. BMC Pediatr. 2017; 17(1):7. PMC: 5223413. DOI: 10.1186/s12887-016-0761-0. View

Askenazi D, Griffin R, McGwin G, Carlo W, Ambalavanan N . Acute kidney injury is independently associated with mortality in very low birthweight infants: a matched case-control analysis. Pediatr Nephrol. 2009; 24(5):991-7. DOI: 10.1007/s00467-009-1133-x. View

10.

La Manna G, Galletti S, Capelli I, Vandini S, Nisi K, Aquilano G . Urinary neutrophil gelatinase-associated lipocalin at birth predicts early renal function in very low birth weight infants. Pediatr Res. 2011; 70(4):379-83. DOI: 10.1203/PDR.0b013e31822941c7. View

11.

Simonazzi G, Capelli I, Curti A, Comai G, Rizzo N, La Manna G . Serum and Urinary Neutrophil Gelatinase-associated Lipocalin Monitoring in Normal Pregnancy Versus Pregnancies Complicated by Pre-eclampsia. In Vivo. 2015; 29(1):117-21. View

12.

Hanna M, Brophy P, Giannone P, Joshi M, Bauer J, RamachandraRao S . Early urinary biomarkers of acute kidney injury in preterm infants. Pediatr Res. 2016; 80(2):218-23. DOI: 10.1038/pr.2016.70. View

13.

Frost B, Modi B, Jaksic T, Caplan M . New Medical and Surgical Insights Into Neonatal Necrotizing Enterocolitis: A Review. JAMA Pediatr. 2016; 171(1):83-88. DOI: 10.1001/jamapediatrics.2016.2708. View

14.

Ratiu D, Hide-Moser K, Morgenstern B, Gottschalk I, Eichler C, Ludwig S . Doppler Indices and Notching Assessment of Uterine Artery Between the 19th and 22nd Week of Pregnancy in the Prediction of Pregnancy Outcome. In Vivo. 2019; 33(6):2199-2204. PMC: 6899124. DOI: 10.21873/invivo.11722. View

15.

Askenazi D, Ambalavanan N, Goldstein S . Acute kidney injury in critically ill newborns: what do we know? What do we need to learn?. Pediatr Nephrol. 2008; 24(2):265-74. PMC: 2755786. DOI: 10.1007/s00467-008-1060-2. View

16.

Friedl A, Stoesz S, Buckley P, Gould M . Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. Histochem J. 1999; 31(7):433-41. DOI: 10.1023/a:1003708808934. View

17.

DeFreitas M, Seeherunvong W, Katsoufis C, RamachandraRao S, Duara S, Yasin S . Longitudinal patterns of urine biomarkers in infants across gestational ages. Pediatr Nephrol. 2016; 31(7):1179-88. DOI: 10.1007/s00467-016-3327-3. View

18.

Abitbol C, Rodriguez M . The long-term renal and cardiovascular consequences of prematurity. Nat Rev Nephrol. 2012; 8(5):265-74. DOI: 10.1038/nrneph.2012.38. View

19.

Kukawczynska-Noczynska J, Suchanska R, Berghausen-Mazur M . Echocardiographic ultrasound screening assessment of the circulatory system of newborns delivered at basic level perinatal care centers. Adv Clin Exp Med. 2019; 28(12):1691-1695. DOI: 10.17219/acem/110327. View

20.

Askenazi D, Montesanti A, Hundley H, Koralkar R, Pawar P, Shuaib F . Urine biomarkers predict acute kidney injury and mortality in very low birth weight infants. J Pediatr. 2011; 159(6):907-12.e1. PMC: 5065006. DOI: 10.1016/j.jpeds.2011.05.045. View