Therapeutic Effect of Intense Pulsed Light (IPL) Combined with Meibomian Gland Expression (MGX) on Meibomian Gland Dysfunction (MGD)

Overview

Journal J Ophthalmol

Publisher Wiley

Specialty Ophthalmology

Date 2020 May 1

PMID 32351719

Citations 8

Authors

Shanshan Wei

Xiaotong Ren

Yuexin Wang

Yilin Chou

Xuemin Li

Affiliations

Soon will be listed here.

Abstract

Purpose: Our study aimed to evaluate the efficiency of intense pulsed light (IPL) combined with meibomian gland expression (MGX) in treating meibomian gland dysfunction (MGD).

Methods: This study was a prospective interventional study. A total of 53 patients were included in the study and received a series of three treatments at an interval of 3-4 weeks. Follow-up examinations were completed 4 weeks after the last treatment. The Ocular Surface Disease Index (OSDI) questionnaire, tear meniscus height (TMH), tear break-up time (TBUT), slit-lamp examinations, and in vivo confocal microscopy (IVCM) were recorded before and after treatment. Additionally, an artificial intelligence automated software program was applied in our study for corneal nerve analysis.

Results: The OSDI score was significantly reduced after the IPL treatment compared with baseline ( < 0.001). Meibomian gland assessment scores, including meibum quality and expressibility, eyelid margin abnormalities, and corneal staining, significantly decreased after treatment ( < 0.05). Moreover, the corneal nerve fiber length (CNFL) significantly increased after the treatment ( < 0.001).

Conclusion: Intense pulsed light (IPL) combined with MGX is an effective treatment for MGD, and neurotrophism could be one of the mechanisms of IPL.

Citing Articles

Changes in the distribution of the tear film lipid layer after intensive pulsed light combined with meibomian gland expression in patients with meibomian gland dysfunction.

Lee Y, Lee S, Yun J, Han S, Choi C PLoS One. 2025; 20(2):e0316935.

PMID: 40019876 PMC: 11870382. DOI: 10.1371/journal.pone.0316935.

Effects of combined intense pulsed light and cyclosporine 0.05% eyedrops in ocular surface matrix metalloproteinase-9 levels in patients with moderate-to-severe MGD.

Jeon Y, Bae S, Chung H, Kim J, Lee H Lasers Med Sci. 2024; 39(1):203.

PMID: 39088100 DOI: 10.1007/s10103-024-04154-4.

The photothermal effect of intense pulsed light and LipiFlow in eyelid related ocular surface diseases: Meibomian gland dysfunction, Demodex and blepharitis.

Li H, Huang L, Fang X, Xie Z, Xiao X, Luo S Heliyon. 2024; 10(13):e33852.

PMID: 39040313 PMC: 11261865. DOI: 10.1016/j.heliyon.2024.e33852.

Predicting an unstable tear film through artificial intelligence.

Fineide F, Storas A, Chen X, Magno M, Yazidi A, Riegler M Sci Rep. 2022; 12(1):21416.

PMID: 36496510 PMC: 9741582. DOI: 10.1038/s41598-022-25821-y.

The Utility of Oral Vitamin B1 and Mecobalamin to Improve Corneal Nerves in Dry Eye Disease: An In Vivo Confocal Microscopy Study.

Ren X, Chou Y, Wang Y, Jing D, Chen Y, Li X Nutrients. 2022; 14(18).

PMID: 36145126 PMC: 9504679. DOI: 10.3390/nu14183750.

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