Pediatric Cancer Models in Zebrafish

Overview

Journal Trends Cancer

Publisher Cell Press

Specialty Oncology

Date 2020 Apr 30

PMID 32348736

Citations 21

Authors

Mattie J Casey

Rodney A Stewart

Affiliations

Soon will be listed here.

Abstract

Pediatric cancer is a leading cause of death in children and adolescents. Improvements in pediatric cancer treatment that include the alleviation of long-term adverse effects require a deeper understanding of the genetic, epigenetic, and developmental factors driving these cancers. Here, we review how the unique attributes of the zebrafish model system in embryology, imaging, and scalability have been used to identify new mechanisms of tumor initiation, progression, and relapse and for drug discovery. We focus on zebrafish models of leukemias, neural tumors and sarcomas - the most common and difficult childhood cancers to treat.

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References

Shern J, Yohe M, Khan J . Pediatric Rhabdomyosarcoma. Crit Rev Oncog. 2015; 20(3-4):227-43. PMC: 5486973. DOI: 10.1615/critrevoncog.2015013800. View

Ward E, DeSantis C, Robbins A, Kohler B, Jemal A . Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin. 2014; 64(2):83-103. DOI: 10.3322/caac.21219. View

Zhang J, Walsh M, Wu G, Edmonson M, Gruber T, Easton J . Germline Mutations in Predisposition Genes in Pediatric Cancer. N Engl J Med. 2015; 373(24):2336-2346. PMC: 4734119. DOI: 10.1056/NEJMoa1508054. View

Banerjee A, Jakacki R, Onar-Thomas A, Wu S, Nicolaides T, Poussaint T . A phase I trial of the MEK inhibitor selumetinib (AZD6244) in pediatric patients with recurrent or refractory low-grade glioma: a Pediatric Brain Tumor Consortium (PBTC) study. Neuro Oncol. 2017; 19(8):1135-1144. PMC: 5570236. DOI: 10.1093/neuonc/now282. View

Gutierrez A, Grebliunaite R, Feng H, Kozakewich E, Zhu S, Guo F . Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J Exp Med. 2011; 208(8):1595-603. PMC: 3149218. DOI: 10.1084/jem.20101691. View

Hayes M, Langenau D . Discovering novel oncogenic pathways and new therapies using zebrafish models of sarcoma. Methods Cell Biol. 2017; 138:525-561. DOI: 10.1016/bs.mcb.2016.11.011. View

Shin J, Padmanabhan A, de Groh E, Lee J, Haidar S, Dahlberg S . Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Dis Model Mech. 2012; 5(6):881-94. PMC: 3484870. DOI: 10.1242/dmm.009779. View

Ignatius M, Hayes M, Moore F, Tang Q, Garcia S, Blackburn P . deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish. Elife. 2018; 7. PMC: 6128690. DOI: 10.7554/eLife.37202. View

Lilljebjorn H, Fioretos T . New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia. Blood. 2017; 130(12):1395-1401. DOI: 10.1182/blood-2017-05-742643. View

10.

Neumann J, Lillard K, Damoulis V, Amatruda J . Zebrafish models of germ cell tumor. Methods Cell Biol. 2011; 105:3-24. PMC: 3932324. DOI: 10.1016/B978-0-12-381320-6.00001-1. View

11.

Zimmerman M, Liu Y, He S, Durbin A, Abraham B, Easton J . Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. Cancer Discov. 2017; 8(3):320-335. PMC: 5856009. DOI: 10.1158/2159-8290.CD-17-0993. View

12.

Chen E, DeRan M, Ignatius M, Grandinetti K, Clagg R, McCarthy K . Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2014; 111(14):5349-54. PMC: 3986146. DOI: 10.1073/pnas.1317731111. View

13.

Solin S, Shive H, Woolard K, Essner J, McGrail M . Rapid tumor induction in zebrafish by TALEN-mediated somatic inactivation of the retinoblastoma1 tumor suppressor rb1. Sci Rep. 2015; 5:13745. PMC: 4642565. DOI: 10.1038/srep13745. View

14.

Sturm D, Orr B, Toprak U, Hovestadt V, Jones D, Capper D . New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. Cell. 2016; 164(5):1060-1072. PMC: 5139621. DOI: 10.1016/j.cell.2016.01.015. View

15.

Blackburn J, Liu S, Wilder J, Dobrinski K, Lobbardi R, Moore F . Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation. Cancer Cell. 2014; 25(3):366-78. PMC: 3992437. DOI: 10.1016/j.ccr.2014.01.032. View

16.

Burns M, Liao Z, Yamagata N, Pouliot G, Stevenson K, Neuberg D . Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 2018; 32(10):2126-2137. PMC: 6148437. DOI: 10.1038/s41375-018-0097-x. View

17.

Letrado P, de Miguel I, Lamberto I, Diez-Martinez R, Oyarzabal J . Zebrafish: Speeding Up the Cancer Drug Discovery Process. Cancer Res. 2018; 78(21):6048-6058. DOI: 10.1158/0008-5472.CAN-18-1029. View

18.

Tao T, Sondalle S, Shi H, Zhu S, Perez-Atayde A, Peng J . The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma. Oncogene. 2017; 36(27):3852-3867. PMC: 5501763. DOI: 10.1038/onc.2016.527. View

19.

White R, Rose K, Zon L . Zebrafish cancer: the state of the art and the path forward. Nat Rev Cancer. 2013; 13(9):624-36. PMC: 6040891. DOI: 10.1038/nrc3589. View

20.

Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn J, Abraham B . TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discov. 2017; 7(11):1336-1353. PMC: 5683427. DOI: 10.1158/2159-8290.CD-17-0267. View