Circadian Rhythm Disruption and Alzheimer's Disease: The Dynamics of a Vicious Cycle

Overview

Journal Curr Neuropharmacol

Publisher Bentham Science Publishers

Date 2020 Apr 30

PMID 32348224

Citations 18

Authors

Ashish Sharma

Gautam Sethi

Murtaza M Tambuwala

Alaa A A Aljabali

Dinesh Kumar Chellappan

Kamal Dua

Rohit Goyal

Affiliations

Soon will be listed here.

Abstract

All mammalian cells exhibit circadian rhythm in cellular metabolism and energetics. Autonomous cellular clocks are modulated by various pathways that are essential for robust time keeping. In addition to the canonical transcriptional translational feedback loop, several new pathways of circadian timekeeping - non-transcriptional oscillations, post-translational modifications, epigenetics and cellular signaling in the circadian clock - have been identified. The physiology of circadian rhythm is expansive, and its link to the neurodegeneration is multifactorial. Circadian rhythm disruption is prevelant in contamporary society where light-noise, shift-work, and transmeridian travel are commonplace, and is also reported from the early stages of Alzheimer's disease (AD). Circadian alignment by bright light therapy in conjunction with chronobiotics is beneficial for treating sundowning syndrome and other cognitive symptoms in advanced AD patients. We performed a comprehensive analysis of the clinical and translational reports to review the physiology of the circadian clock, delineate its dysfunction in AD, and unravel the dynamics of the vicious cycle between two pathologies. The review delineates the role of putative targets like clock proteins PER, CLOCK, BMAL1, ROR, and clock-controlled proteins like AVP, SIRT1, FOXO, and PK2 towards future approaches for management of AD. Furthermore, the role of circadian rhythm disruption in aging is delineated.

Citing Articles

BMAL1 upregulates STX17 levels to promote autophagosome-lysosome fusion in hippocampal neurons to ameliorate Alzheimer's disease.

Zhou X, Du K, Mao T, Wang N, Zhang L, Tian Y iScience. 2024; 27(12):111413.

PMID: 39687016 PMC: 11647228. DOI: 10.1016/j.isci.2024.111413.

Molecular clues unveiling spinocerebellar ataxia type-12 pathogenesis.

Kumar M, Sahni S, A V, Kumar D, Kushwah N, Goel D iScience. 2024; 27(5):109768.

PMID: 38711441 PMC: 11070597. DOI: 10.1016/j.isci.2024.109768.

Modulation of the Circadian Rhythm and Oxidative Stress as Molecular Targets to Improve Vascular Dementia: A Pharmacological Perspective.

Trujillo-Rangel W, Acuna-Vaca S, Padilla-Ponce D, Garcia-Mercado F, Torres-Mendoza B, Pacheco-Moises F Int J Mol Sci. 2024; 25(8).

PMID: 38673986 PMC: 11050388. DOI: 10.3390/ijms25084401.

The amyloid precursor protein intracellular domain induces sleep disruptions and its nuclear localization fluctuates in circadian pacemaker neurons in Drosophila and mice.

Long D, Cravetchi O, Chow E, Allen C, Kretzschmar D Neurobiol Dis. 2024; 192:106429.

PMID: 38309627 PMC: 10932905. DOI: 10.1016/j.nbd.2024.106429.

Analyzing alternative splicing in Alzheimer's disease postmortem brain: a cell-level perspective.

Farhadieh M, Ghaedi K Front Mol Neurosci. 2023; 16:1237874.

PMID: 37799732 PMC: 10548223. DOI: 10.3389/fnmol.2023.1237874.

References

Li H, SATINOFF E . Fetal tissue containing the suprachiasmatic nucleus restores multiple circadian rhythms in old rats. Am J Physiol. 1998; 275(6):R1735-44. DOI: 10.1152/ajpregu.1998.275.6.R1735. View

Wisor J, Pasumarthi R, Gerashchenko D, Thompson C, Pathak S, Sancar A . Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains. J Neurosci. 2008; 28(28):7193-201. PMC: 2603080. DOI: 10.1523/JNEUROSCI.1150-08.2008. View

Benedict C, Cedernaes J, Giedraitis V, Nilsson E, Hogenkamp P, Vagesjo E . Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men. Sleep. 2014; 37(1):195-8. PMC: 3902870. DOI: 10.5665/sleep.3336. View

Pritchett D, Reddy A . No FAD, No CRY: Redox and Circadian Rhythms. Trends Biochem Sci. 2017; 42(7):497-499. DOI: 10.1016/j.tibs.2017.05.007. View

LeVault K, Tischkau S, Brewer G . Circadian Disruption Reveals a Correlation of an Oxidative GSH/GSSG Redox Shift with Learning and Impaired Memory in an Alzheimer's Disease Mouse Model. J Alzheimers Dis. 2015; 49(2):301-16. DOI: 10.3233/JAD-150026. View

Yamazaki S, Numano R, Abe M, Hida A, Takahashi R, Ueda M . Resetting central and peripheral circadian oscillators in transgenic rats. Science. 2000; 288(5466):682-5. DOI: 10.1126/science.288.5466.682. View

Wible R, Ramanathan C, Sutter C, Olesen K, Kensler T, Liu A . NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in . Elife. 2018; 7. PMC: 5826263. DOI: 10.7554/eLife.31656. View

Nakamura T, Nakamura W, Yamazaki S, Kudo T, Cutler T, Colwell C . Age-related decline in circadian output. J Neurosci. 2011; 31(28):10201-5. PMC: 3155746. DOI: 10.1523/JNEUROSCI.0451-11.2011. View

Eide E, Woolf M, Kang H, Woolf P, Hurst W, Camacho F . Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol Cell Biol. 2005; 25(7):2795-807. PMC: 1061645. DOI: 10.1128/MCB.25.7.2795-2807.2005. View

10.

Cho H, Jin S, Youn H, Huh K, Mook-Jung I . Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling. Aging Cell. 2007; 7(2):137-47. DOI: 10.1111/j.1474-9726.2007.00360.x. View

11.

Wyse C, Coogan A . Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain. Brain Res. 2010; 1337:21-31. DOI: 10.1016/j.brainres.2010.03.113. View

12.

Takahashi J, Hong H, Ko C, McDearmon E . The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet. 2008; 9(10):764-75. PMC: 3758473. DOI: 10.1038/nrg2430. View

13.

Peng W, Achariyar T, Li B, Liao Y, Mestre H, Hitomi E . Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease. Neurobiol Dis. 2016; 93:215-25. PMC: 4980916. DOI: 10.1016/j.nbd.2016.05.015. View

14.

Yun H, Jin P, Han J, Lee M, Han S, Oh K . Acceleration of the development of Alzheimer's disease in amyloid beta-infused peroxiredoxin 6 overexpression transgenic mice. Mol Neurobiol. 2013; 48(3):941-51. DOI: 10.1007/s12035-013-8479-6. View

15.

Sharma M, Schwartz G, Iskandar H, Thakur M, Quirion R, Nair N . Circadian rhythms of melatonin and cortisol in aging. Biol Psychiatry. 1989; 25(3):305-19. DOI: 10.1016/0006-3223(89)90178-9. View

16.

Kim S, Fountoulakis M, Cairns N, Lubec G . Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome. J Neural Transm Suppl. 2002; (61):223-35. DOI: 10.1007/978-3-7091-6262-0_18. View

17.

LeGates T, Altimus C, Wang H, Lee H, Yang S, Zhao H . Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature. 2012; 491(7425):594-8. PMC: 3549331. DOI: 10.1038/nature11673. View

18.

Asayama K, Yamadera H, Ito T, Suzuki H, Kudo Y, Endo S . Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch. 2003; 70(4):334-41. DOI: 10.1272/jnms.70.334. View

19.

van der Horst G, Muijtjens M, Kobayashi K, Takano R, Kanno S, Takao M . Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature. 1999; 398(6728):627-30. DOI: 10.1038/19323. View

20.

Kondratov R, Kondratova A, Gorbacheva V, Vykhovanets O, Antoch M . Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev. 2006; 20(14):1868-73. PMC: 1522083. DOI: 10.1101/gad.1432206. View