From Genetics to Genomics: Facing the Liability Implications in Clinical Care

Overview

Journal J Law Med Ethics

Publisher Cambridge University Press

Specialties Forensic Sciences
General Medicine
Health Services
Medical Ethics

Date 2020 Apr 29

PMID 32342786

Citations 25

Authors

Gary Marchant

Mark Barnes

James P Evans

Bonnie LeRoy

Susan M Wolf

Affiliations

Soon will be listed here.

Abstract

Health care is transitioning from genetics to genomics, in which single-gene testing for diagnosis is being replaced by multi-gene panels, genome-wide sequencing, and other multi-genic tests for disease diagnosis, prediction, prognosis, and treatment. This health care transition is spurring a new set of increased or novel liability risks for health care providers and test laboratories. This article describes this transition in both medical care and liability, and addresses 11 areas of potential increased or novel liability risk, offering recommendations to both health care and legal actors to address and manage those liability risks.

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A Copernican revolution of multigenic analysis: A retrospective study on clinical exome sequencing in unclear genetic disorders.

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Exploring Genetic Testing for Rare Disorders of Obesity: Experience and Perspectives of Pediatric Weight Management Providers.

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When Germline Genetic Testing Results Are Unclear: Highlighting Variants of Uncertain Significance.

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Opt-in for secondary findings as part of diagnostic whole-exome sequencing: Real-life experience from an international diagnostic laboratory.

Brunfeldt M, Kaare M, Saarinen I, Koskenvuo J, Kaariainen H Mol Genet Genomic Med. 2023; 11(8):e2180.

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