Evaluation Inflammatory Markers of Hemogram Parameters in Primary Ovarian Insufficiency

Overview

Journal Turk J Obstet Gynecol

Specialty Gynecology & Obstetrics

Date 2020 Apr 29

PMID 32341824

Citations 2

Authors

Bulent Demir

Sureyya Saridas Demir

Kubra Ozkan Karacaer

Semir Pasa

Fatma Silan

Affiliations

Soon will be listed here.

Abstract

Objective: In most of primary ovarian insufficiency (POI) cases, etiologic factors have not been fully elucidated. Recent studies have revealed that inflammatory agents play an important role in the etiopathogenesis of POI. Therefore, the aim of this study was to investigate the role of inflammatory markers of hemogram parameters in POI.

Materials And Methods: The study compared 47 healthy women and 47 women diagnosed as having POI retrospectively by scanning electronic and written recording systems. Complete blood counts, day-3 hormone profiles levels of all subjects were analyzed. The neutrophil-lymphocyte ratio (NLR), red cell distribution width (RDW), platelet ratio (RPR), platelet lymphocyte ratio (PLR), and mean platelet volume (MPV) mean platelet lymphocyte ratio (MPLR) were calculated from the complete blood count parameters.

Results: White blood cell and MPV values, platelet, and lymphocyte counts were significantly higher in the POI patients (p<0.001, p=0.042, p=0.038, p=0.049, respectively), RPR was significantly lower than the control group (p=0.011), but there were no significant differences in hemoglobin, RDW, NLR, PLR, and MPLR (p=0.454, p=0.057, p=0.635, p=0.780, p=0.126, respectively). The neutrophil count of the study group was higher than in the control group (p=0.057). Bivariate correlation analyses showed no correlations between blood parameters and hormone levels. The area under the receiver operating characteristic curve for RPR in POI was 0.652, with a threshold value 0.053, sensitivity=63% and specificity=63.

Conclusion: Inflammatory markers of hemogram detected higher in patients with POI then control subjects.

Citing Articles

Hematological Indices and Genetic Variants of Premature Ovarian Insufficiency: Machine Learning Approaches.

Mirinezhad M, Aghasizadeh M, Ghazizadeh H, Hemmatpur A, Mashhadi M, Khedmatgozar H Cardiovasc Hematol Disord Drug Targets. 2024; 24(2):98-109.

PMID: 38910412 DOI: 10.2174/011871529X297081240613075328.

Gender Difference in the Associations among Heavy Metals with Red Blood Cell Hemogram.

Huang C, Wang C, Chen H, Tu H, Chen S, Hung C Int J Environ Res Public Health. 2022; 19(1).

PMID: 35010453 PMC: 8750598. DOI: 10.3390/ijerph19010189.

References

Azab B, Jaglall N, Atallah J, Lamet A, Raja-Surya V, Farah B . Neutrophil-lymphocyte ratio as a predictor of adverse outcomes of acute pancreatitis. Pancreatology. 2011; 11(4):445-52. DOI: 10.1159/000331494. View

Reato G, Morlin L, Chen S, Furmaniak J, Rees Smith B, Masiero S . Premature ovarian failure in patients with autoimmune Addison's disease: clinical, genetic, and immunological evaluation. J Clin Endocrinol Metab. 2011; 96(8):E1255-61. DOI: 10.1210/jc.2011-0414. View

Cho H, Hur H, Kim S, Kim S, Kim J, Kim Y . Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother. 2008; 58(1):15-23. PMC: 11029845. DOI: 10.1007/s00262-008-0516-3. View

Betterle C, Volpato M, Rees Smith B, Furmaniak J, Chen S, Greggio N . I. Adrenal cortex and steroid 21-hydroxylase autoantibodies in adult patients with organ-specific autoimmune diseases: markers of low progression to clinical Addison's disease. J Clin Endocrinol Metab. 1997; 82(3):932-8. DOI: 10.1210/jcem.82.3.3819. View

Stotz M, Gerger A, Eisner F, Szkandera J, Loibner H, Ress A . Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer. Br J Cancer. 2013; 109(2):416-21. PMC: 3721392. DOI: 10.1038/bjc.2013.332. View

Singh N, Dadhwal V, Sharma K, Mittal S . Xanthogranulomatous inflammation: a rare cause of premature ovarian failure. Arch Gynecol Obstet. 2008; 279(5):729-31. DOI: 10.1007/s00404-008-0791-4. View

Straub R . The complex role of estrogens in inflammation. Endocr Rev. 2007; 28(5):521-74. DOI: 10.1210/er.2007-0001. View

Coulam C, Adamson S, Annegers J . Incidence of premature ovarian failure. Obstet Gynecol. 1986; 67(4):604-6. View

Sanverdi I, Kilicci C, Cogendez E, Abide Yayla C, Ozkaya E . Utility of complete blood count parameters to detect premature ovarian insufficiency in cases with oligomenorrhea/amenorrhea. J Clin Lab Anal. 2017; 32(5):e22372. PMC: 6817150. DOI: 10.1002/jcla.22372. View

10.

Sharif K, Watad A, Bridgewood C, Kanduc D, Amital H, Shoenfeld Y . Insights into the autoimmune aspect of premature ovarian insufficiency. Best Pract Res Clin Endocrinol Metab. 2019; 33(6):101323. DOI: 10.1016/j.beem.2019.101323. View

11.

Rudnicka E, Kruszewska J, Klicka K, Kowalczyk J, Grymowicz M, Skorska J . Premature ovarian insufficiency - aetiopathology, epidemiology, and diagnostic evaluation. Prz Menopauzalny. 2018; 17(3):105-108. PMC: 6196779. DOI: 10.5114/pm.2018.78550. View

12.

Franic-Ivanisevic M, Franic D, Ivovic M, Tancic-Gajic M, Marina L, Barac M . Genetic Etiology of Primary Premature Ovarian Insufficiency. Acta Clin Croat. 2017; 55(4):629-635. DOI: 10.20471/acc.2016.55.04.14. View

13.

Cramer D, Xu H . Predicting age at menopause. Maturitas. 1996; 23(3):319-26. DOI: 10.1016/0378-5122(96)00992-9. View

14.

Silvestri A, Gebara O, Vitale C, Wajngarten M, Leonardo F, Ramires J . Increased levels of C-reactive protein after oral hormone replacement therapy may not be related to an increased inflammatory response. Circulation. 2003; 107(25):3165-9. DOI: 10.1161/01.CIR.0000074208.02226.5E. View

15.

Sen A, Kushnir V, Barad D, Gleicher N . Endocrine autoimmune diseases and female infertility. Nat Rev Endocrinol. 2013; 10(1):37-50. DOI: 10.1038/nrendo.2013.212. View

16.

Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M . The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology. 2008; 73(3-4):215-20. DOI: 10.1159/000127412. View

17.

Petrikova J, Lazurova I . Ovarian failure and polycystic ovary syndrome. Autoimmun Rev. 2011; 11(6-7):A471-8. DOI: 10.1016/j.autrev.2011.11.010. View

18.

Webber L, Davies M, Anderson R, Bartlett J, Braat D, Cartwright B . ESHRE Guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2016; 31(5):926-37. DOI: 10.1093/humrep/dew027. View

19.

Sammaritano L . Menopause in patients with autoimmune diseases. Autoimmun Rev. 2011; 11(6-7):A430-6. DOI: 10.1016/j.autrev.2011.11.006. View

20.

Chen B, Ye B, Zhang J, Ying L, Chen Y . RDW to platelet ratio: a novel noninvasive index for predicting hepatic fibrosis and cirrhosis in chronic hepatitis B. PLoS One. 2013; 8(7):e68780. PMC: 3714293. DOI: 10.1371/journal.pone.0068780. View