The Role of CARD9 in Metabolic Diseases

Overview

Journal Curr Med Sci

Specialty General Medicine

Date 2020 Apr 28

PMID 32337681

Citations 11

Authors

Cheng Tian

Ya-Li Tuo

Yi Lu

Chuan-Rui Xu

Ming Xiang

Affiliations

Soon will be listed here.

Abstract

Caspase recruitment domain containing protein 9 (CARD9) is an adaptor protein that plays a critical role in pattern recognition receptors (PRRs)-mediated activation of NF-?B and mitogen-activated protein kinase (MAPK). This elicits initiation of the pro-inflammatory cytokines and leads to inflammatory responses, which has been recognized as a critical contributor to chronic inflammation. Current researches demonstrate that CARD9 is strongly associated with metabolic diseases, such as obesity, insulin resistance, atherosclerosis and so on. In this review, we summarize CARD9 signaling pathway and the role of CARD9 in metabolic diseases.

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