Predictive Factors for Local Control of Early Glottic Squamous Cell Carcinomas After Definitive Radiotherapy

Overview

Journal Mol Clin Oncol

Specialty Oncology

Date 2020 Apr 28

PMID 32337036

Citations 3

Authors

Mitsuru Okubo

Tomohiro Itonaga

Tatsuhiko Saito

Sachika Shiraishi

Ryuji Mikami

Akira Sakurada

Shinji Sugahara

Jinho Park

Koichi Tokuuye

Kazuhiro Saito

Affiliations

Soon will be listed here.

Abstract

The aim of the present study was to retrospectively investigate the risk factors of local failure for T1 glottic carcinoma irradiated with a prescription dose of 66 Gy. Between July 2006 and December 2017, 64 patients with T1 glottic squamous cell carcinoma treated with 66 Gy/33 fractions were analyzed for risk factors of local failure. The sex, age, performance status, T stage, overall treatment time, anterior commissure involvement, smoking status during/after treatment, histological tumor grade and pretreatment hemoglobin level were investigated. The maximum, mean and minimum doses, and the homogeneity index for the glottic larynx were calculated for dosimetric risk factors of local failure. The median follow-up duration was 51 months. Local failure was observed in 6 patients (9.5%). Among all risk factors, only the minimum dose to the glottic larynx was found to be significantly associated with local failure (P=0.025). The 5-year local control rates for a minimum dose to the glottic larynx of <65 and ≥65 Gy were 79 and 95%, respectively, with a statistically significant difference (P=0.015). No patients exhibited grade ≥3 late adverse effects. The minimum dose to the glottic larynx was the only factor significantly associated with local failure. Thus, local control of T1 glottic carcinoma may improve with a minimum dose of ≥65 Gy to the glottic larynx. In conclusion, radiotherapy with a minimum prescription dose of ≥65 Gy to the glottic larynx appears to be safe and achieves a high local control rate for T1 glottic carcinoma.

Citing Articles

The outcome of early-stage glottic carcinoma patients treated with radiotherapy: Egyptian National Cancer Institute (NCI-Egypt) experience.

Mohamed A, Hassouna A, Mosalum H, Alnagmy A, Ashour M Rep Pract Oncol Radiother. 2023; 28(4):496-505.

PMID: 37795222 PMC: 10547425. DOI: 10.5603/RPOR.a2023.0052.

The Comparison of Electroacoustic and Subjective Voice Quality in Type 3 and 4 Transoral Laser Cordectomy for Early-Stage Glottic Carcinoma.

Ozturk K, Turhal G, Sahin F, Sezgin B Indian J Otolaryngol Head Neck Surg. 2023; 75(2):680-684.

PMID: 37275100 PMC: 10235358. DOI: 10.1007/s12070-022-03342-4.

Predicting risk factors for hypothyroidism after definitive radiotherapy for early glottic carcinomas.

Okubo M, Itonaga T, Saito T, Yunaiyama D, Mikami R, Okada Y Oncol Lett. 2022; 25(1):17.

PMID: 36466995 PMC: 9713759. DOI: 10.3892/ol.2022.13603.

References

Murakami R, Nishimura R, Baba Y, Furusawa M, Ogata N, Yumoto E . Prognostic factors of glottic carcinomas treated with radiation therapy: value of the adjacent sign on radiological examinations in the sixth edition of the UICC TNM staging system. Int J Radiat Oncol Biol Phys. 2005; 61(2):471-5. DOI: 10.1016/j.ijrobp.2004.05.024. View

Small Jr W, Mittal B, Brand W, Shetty R, Rademaker A, Beck G . Results of radiation therapy in early glottic carcinoma: multivariate analysis of prognostic and radiation therapy variables. Radiology. 1992; 183(3):789-94. DOI: 10.1148/radiology.183.3.1584935. View

Eskiizmir G, Baskin Y, Yalcin F, Ellidokuz H, Ferris R . Risk factors for radiation failure in early-stage glottic carcinoma: A systematic review and meta-analysis. Oral Oncol. 2016; 62:90-100. DOI: 10.1016/j.oraloncology.2016.10.013. View

Mendenhall W, Parsons J, Stringer S, Cassisi N, Million R . T1-T2 vocal cord carcinoma: a basis for comparing the results of radiotherapy and surgery. Head Neck Surg. 1988; 10(6):373-7. DOI: 10.1002/hed.2890100603. View

Beitler J, Johnson J . Transoral laser excision for early glottic cancer. Int J Radiat Oncol Biol Phys. 2003; 56(4):1063-6. DOI: 10.1016/s0360-3016(03)00412-7. View

Nishimura Y, Nagata Y, Okajima K, Mitsumori M, Hiraoka M, Masunaga S . Radiation therapy for T1,2 glottic carcinoma: impact of overall treatment time on local control. Radiother Oncol. 1996; 40(3):225-32. DOI: 10.1016/0167-8140(96)01796-3. View

Sakata K, Aoki Y, Karasawa K, Hasezawa K, MUTA N, Nakagawa K . Radiation therapy in early glottic carcinoma: uni- and multivariate analysis of prognostic factors affecting local control. Int J Radiat Oncol Biol Phys. 1994; 30(5):1059-64. DOI: 10.1016/0360-3016(94)90310-7. View

Mendenhall W, Werning J, Hinerman R, Amdur R, Villaret D . Management of T1-T2 glottic carcinomas. Cancer. 2004; 100(9):1786-92. DOI: 10.1002/cncr.20181. View

Berwouts D, Swimberghe M, Duprez F, Boterberg T, Bonte K, Deron P . Intensity-modulated radiotherapy for early-stage glottic cancer. Head Neck. 2014; 38 Suppl 1:E179-84. DOI: 10.1002/hed.23967. View

10.

Zhao K, Liu G, Jiang G, Zhong L, Wang Y, Yao W . Association of haemoglobin level with morbidity and mortality of patients with locally advanced oesophageal carcinoma undergoing radiotherapy--a secondary analysis of three consecutive clinical phase III trials. Clin Oncol (R Coll Radiol). 2006; 18(8):621-7. DOI: 10.1016/j.clon.2006.04.015. View

11.

Back G, Sood S . The management of early laryngeal cancer: options for patients and therapists. Curr Opin Otolaryngol Head Neck Surg. 2005; 13(2):85-91. DOI: 10.1097/01.moo.0000156168.63204.70. View

12.

Nur D, Oguz C, Kemal E, Ferhat E, Sulen S, Emel A . Prognostic factors in early glottic carcinoma implications for treatment. Tumori. 2005; 91(2):182-7. DOI: 10.1177/030089160509100215. View

13.

Kataria T, Sharma K, Subramani V, Karrthick K, Bisht S . Homogeneity Index: An objective tool for assessment of conformal radiation treatments. J Med Phys. 2013; 37(4):207-13. PMC: 3532749. DOI: 10.4103/0971-6203.103606. View

14.

Shin N, Lee Y, Kim S, Choi C, Kim T, Lee J . Prognostic value of pretreatment hemoglobin level in patients with early cervical cancer. Obstet Gynecol Sci. 2014; 57(1):28-36. PMC: 3924748. DOI: 10.5468/ogs.2014.57.1.28. View

15.

Reddy S, Hong R, Nagda S, Emami B . Effect of tumor bulk on local control and survival of patients with T1 glottic cancer: a 30-year experience. Int J Radiat Oncol Biol Phys. 2007; 69(5):1389-94. DOI: 10.1016/j.ijrobp.2007.05.077. View

16.

Al-Mamgani A, van Rooij P, Woutersen D, Mehilal R, Tans L, Monserez D . Radiotherapy for T1-2N0 glottic cancer: a multivariate analysis of predictive factors for the long-term outcome in 1050 patients and a prospective assessment of quality of life and voice handicap index in a subset of 233 patients. Clin Otolaryngol. 2013; 38(4):306-12. DOI: 10.1111/coa.12139. View

17.

Fein D, Lee W, Hanlon A, Ridge J, Curran W, Coia L . Do overall treatment time, field size, and treatment energy influence local control of T1-T2 squamous cell carcinomas of the glottic larynx?. Int J Radiat Oncol Biol Phys. 1996; 34(4):823-31. DOI: 10.1016/0360-3016(95)02205-8. View

18.

Franchin G, Minatel E, Gobitti C, Talamini R, Sartor G, Caruso G . Radiation treatment of glottic squamous cell carcinoma, stage I and II: analysis of factors affecting prognosis. Int J Radiat Oncol Biol Phys. 1998; 40(3):541-8. DOI: 10.1016/s0360-3016(97)00768-2. View

19.

Rudoltz M, Benammar A, Mohiuddin M . Prognostic factors for local control and survival in T1 squamous cell carcinoma of the glottis. Int J Radiat Oncol Biol Phys. 1993; 26(5):767-72. DOI: 10.1016/0360-3016(93)90490-m. View

20.

Akine Y, Tokita N, Ogino T, Tsukiyama I, Egawa S, Saikawa M . Radiotherapy of T1 glottic cancer with 6 MeV X rays. Int J Radiat Oncol Biol Phys. 1991; 20(6):1215-8. DOI: 10.1016/0360-3016(91)90230-2. View