Redox Toxicology of Environmental Chemicals Causing Oxidative Stress

Overview

Journal Redox Biol

Specialties Biology
Cell Biology
Endocrinology

Date 2020 Apr 28

PMID 32336668

Citations 46

Authors

Fuli Zheng

Filipe Marques Goncalves

Yumi Abiko

Huangyuan Li

Yoshito Kumagai

Michael Aschner

Affiliations

Soon will be listed here.

Abstract

Living organisms are surrounded with heavy metals such as methylmercury, manganese, cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or atmospheric pollutants such as quinone. Extensive studies have demonstrated a strong link between environmental pollutants and human health. Redox toxicity is proposed as one of the main mechanisms of chemical-induced pathology in humans. Acting as both a sensor of oxidative stress and a positive regulator of antioxidants, the nuclear factor erythroid 2-related factor 2 (NRF2) has attracted recent attention. However, the role NRF2 plays in environmental pollutant-induced toxicity has not been systematically addressed. Here, we characterize NRF2 function in response to various pollutants, such as metals, pesticides and atmospheric quinones. NRF2 related signaling pathways and epigenetic regulations are also reviewed.

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