Hyaluronic Acid-Functionalized Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging-Guided Radiotherapy of Tumors

Overview

Journal Nanoscale Res Lett

Publisher Springer

Specialty Biotechnology

Date 2020 Apr 27

PMID 32335719

Citations 7

Authors

Chaoyang Wu

Rong Cai

Tian Zhao

Lin Wu

LiRong Zhang

Jie Jin

Lixia Xu

Pengfei Li

Tao Li

Miaomiao Zhang

Fengyi Du

Affiliations

Soon will be listed here.

Abstract

Inaccuracy localization and intrinsic radioresistance of solid tumors seriously hindered the clinical implementation of radiotherapy. In this study, we fabricated hyaluronic acid-functionalized gadolinium oxide nanoparticles (HA-GdO NPs) via one-pot hydrothermal process for effective magnetic resonance (MR) imaging and radiosensitization of tumors. By virtue of HA functionalization, the as-prepared HA-GdO NPs with a diameter of 105 nm showed favorable dispersibility in water, low cytotoxicity, and excellent biocompatibility and readily entered into the cytoplasm of cancer cells by HA receptor-mediated endocytosis. Importantly, HA-GdO NPs exhibited high longitudinal relaxivity (r) 6.0 mMS as MRI contrast agents and radiosensitization enhancement in a dose-dependent manner. These finds demonstrated that as-synthesized HA-GdO NPs as bifunctional theranostic agents have great potential in tumors diagnosis and radiotherapy.

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