Endocrine Disrupting Chemicals and Type 1 Diabetes

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Apr 26

PMID 32331412

Citations 30

Authors

Barbara Predieri

Patrizia Bruzzi

Elena Bigi

Silvia Ciancia

Simona F Madeo

Laura Lucaccioni

Lorenzo Iughetti

Affiliations

Soon will be listed here.

Abstract

Type 1 diabetes (T1D) is the most common chronic metabolic disease in children and adolescents. The etiology of T1D is not fully understood but it seems multifactorial. The genetic background determines the predisposition to develop T1D, while the autoimmune process against β-cells seems to be also determined by environmental triggers, such as endocrine disrupting chemicals (EDCs). Environmental EDCs may act throughout different temporal windows as single chemical agent or as chemical mixtures. They could affect the development and the function of the immune system or of the β-cells function, promoting autoimmunity and increasing the susceptibility to autoimmune attack. Human studies evaluating the potential role of exposure to EDCs on the pathogenesis of T1D are few and demonstrated contradictory results. The aim of this narrative review is to summarize experimental and epidemiological studies on the potential role of exposure to EDCs in the development of T1D. We highlight what we know by animals about EDCs' effects on mechanisms leading to T1D development and progression. Studies evaluating the EDC levels in patients with T1D were also reported. Moreover, we discussed why further studies are needed and how they should be designed to better understand the causal mechanisms and the next prevention interventions.

Citing Articles

Associations Between Daily-Use Products and Urinary Biomarkers of Endocrine-Disrupting Chemicals in Adults of Reproductive Age.

Foley J, Kwiatkowski C, Rochester J, Neveux I, Dabe S, Lathrop M Int J Environ Res Public Health. 2025; 22(1).

PMID: 39857552 PMC: 11764522. DOI: 10.3390/ijerph22010099.

Endocrine Disruptors in Child Obesity and Related Disorders: Early Critical Windows of Exposure.

Celik M, Yesildemir O Curr Nutr Rep. 2025; 14(1):14.

PMID: 39775248 PMC: 11706864. DOI: 10.1007/s13668-024-00604-1.

Endocrine-Disrupting Chemicals and the Development of Diabetes Mellitus Type 1: A 5-Year Systematic Review.

Keskesiadou G, Tsokkou S, Konstantinidis I, Georgaki M, Sioga A, Papamitsou T Int J Mol Sci. 2024; 25(18).

PMID: 39337594 PMC: 11432464. DOI: 10.3390/ijms251810111.

Mechanisms underlying sex differences in autoimmunity.

Fairweather D, Beetler D, McCabe E, Lieberman S J Clin Invest. 2024; 134(18).

PMID: 39286970 PMC: 11405048. DOI: 10.1172/JCI180076.

Endocrine disrupting chemicals and obesity prevention: scoping review.

Amon M, Kek T, Klun I J Health Popul Nutr. 2024; 43(1):138.

PMID: 39227884 PMC: 11373446. DOI: 10.1186/s41043-024-00627-y.

References

Choi J, Eum S, Rampersaud E, Daunert S, Abreu M, Toborek M . Exercise attenuates PCB-induced changes in the mouse gut microbiome. Environ Health Perspect. 2013; 121(6):725-30. PMC: 3672930. DOI: 10.1289/ehp.1306534. View

Hu J, Raikhel V, Gopalakrishnan K, Fernandez-Hernandez H, Lambertini L, Manservisi F . Effect of postnatal low-dose exposure to environmental chemicals on the gut microbiome in a rodent model. Microbiome. 2016; 4(1):26. PMC: 4906585. DOI: 10.1186/s40168-016-0173-2. View

Grammatiki M, Karras S, Kotsa K . The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review. Hormones (Athens). 2018; 18(1):37-48. DOI: 10.1007/s42000-018-0063-z. View

Kaur N, Starling A, Calafat A, Sjodin A, Clouet-Foraison N, Dolan L . Longitudinal association of biomarkers of pesticide exposure with cardiovascular disease risk factors in youth with diabetes. Environ Res. 2019; 181:108916. PMC: 6982582. DOI: 10.1016/j.envres.2019.108916. View

Mustafa A, Holladay S, Witonsky S, Sponenberg D, Karpuzoglu E, Gogal Jr R . A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice. Toxicology. 2011; 290(2-3):156-68. PMC: 3226876. DOI: 10.1016/j.tox.2011.08.021. View

Ahn C, Kang H, Lee J, Hong E, Jung E, Yoo Y . Bisphenol A and octylphenol exacerbate type 1 diabetes mellitus by disrupting calcium homeostasis in mouse pancreas. Toxicol Lett. 2018; 295:162-172. DOI: 10.1016/j.toxlet.2018.06.1071. View

Langer P, Tajtakova M, Guretzki H, Kocan A, Petrik J, Chovancova J . High prevalence of anti-glutamic acid decarboxylase (anti-GAD) antibodies in employees at a polychlorinated biphenyl production factory. Arch Environ Health. 2003; 57(5):412-5. DOI: 10.1080/00039890209601429. View

Atkinson M, Eisenbarth G, Michels A . Type 1 diabetes. Lancet. 2013; 383(9911):69-82. PMC: 4380133. DOI: 10.1016/S0140-6736(13)60591-7. View

Rignell-Hydbom A, Elfving M, Ivarsson S, Lindh C, Jonsson B, Olofsson P . A nested case-control study of intrauterine exposure to persistent organochlorine pollutants in relation to risk of type 1 diabetes. PLoS One. 2010; 5(6):e11281. PMC: 2890585. DOI: 10.1371/journal.pone.0011281. View

10.

Xu J, Huang G, Guo T . Bisphenol S Modulates Type 1 Diabetes Development in Non-Obese Diabetic (NOD) Mice with Diet- and Sex-Related Effects. Toxics. 2019; 7(2). PMC: 6630337. DOI: 10.3390/toxics7020035. View

11.

Gungor D, Nadaud P, LaPergola C, Dreibelbis C, Wong Y, Terry N . Infant milk-feeding practices and diabetes outcomes in offspring: a systematic review. Am J Clin Nutr. 2019; 109(Suppl_7):817S-837S. PMC: 6500931. DOI: 10.1093/ajcn/nqy311. View

12.

Monneret C . What is an endocrine disruptor?. C R Biol. 2017; 340(9-10):403-405. DOI: 10.1016/j.crvi.2017.07.004. View

13.

Lang I, Galloway T, Scarlett A, Henley W, Depledge M, Wallace R . Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA. 2008; 300(11):1303-10. DOI: 10.1001/jama.300.11.1303. View

14.

Grau-Perez M, Kuo C, Spratlen M, Thayer K, Mendez M, Hamman R . The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study. Diabetes Care. 2016; 40(1):46-53. PMC: 5180459. DOI: 10.2337/dc16-0810. View

15.

Craig M, Kim K, Isaacs S, Penno M, Hamilton-Williams E, Couper J . Early-life factors contributing to type 1 diabetes. Diabetologia. 2019; 62(10):1823-1834. DOI: 10.1007/s00125-019-4942-x. View

16.

Brieger A, Bienefeld N, Hasan R, Goerlich R, Haase H . Impact of perfluorooctanesulfonate and perfluorooctanoic acid on human peripheral leukocytes. Toxicol In Vitro. 2011; 25(4):960-8. DOI: 10.1016/j.tiv.2011.03.005. View

17.

Lilienthal H, Fastabend A, Hany J, Kaya H, Dunemann L, Winneke G . Reduced levels of 1,25-dihydroxyvitamin D(3) in rat dams and offspring after exposure to a reconstituted PCB mixture. Toxicol Sci. 2000; 57(2):292-301. DOI: 10.1093/toxsci/57.2.292. View

18.

Bailey R, Cooper J, Zeitels L, Smyth D, Yang J, Walker N . Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes. 2007; 56(10):2616-21. PMC: 2493063. DOI: 10.2337/db07-0652. View

19.

Corsini E, Sangiovanni E, Avogadro A, Galbiati V, Viviani B, Marinovich M . In vitro characterization of the immunotoxic potential of several perfluorinated compounds (PFCs). Toxicol Appl Pharmacol. 2011; 258(2):248-55. DOI: 10.1016/j.taap.2011.11.004. View

20.

Weng J, Zhou Z, Guo L, Zhu D, Ji L, Luo X . Incidence of type 1 diabetes in China, 2010-13: population based study. BMJ. 2018; 360:j5295. PMC: 5750780. DOI: 10.1136/bmj.j5295. View