Earliest Cases of Coronavirus Disease 2019 (COVID-19) Identified in Solid Organ Transplant Recipients in the United States

Overview

Journal Am J Transplant

Publisher Elsevier

Specialty General Surgery

Date 2020 Apr 25

PMID 32330356

Citations 62

Authors

Olivia S Kates

Cynthia E Fisher

Helen C Stankiewicz-Karita

Amanda K Shepherd

E Chandler Church

Siddhartha G Kapnadak

Erika D Lease

Francis X Riedo

Robert M Rakita

Ajit P Limaye

Affiliations

Soon will be listed here.

Abstract

With the rapidly expanding pandemic of SARS-CoV-2, there is concern that solid organ transplant recipients will be particularly vulnerable to infection and may experience a more severe clinical course. We report four cases of COVID-19 in solid organ transplant recipients including recipients of kidney, liver, lung, and heart transplants. We describe each patient's medical history including transplantation history, their clinical presentation and workup, and their course from diagnosis to either hospital discharge or to improvement in symptoms. These reports demonstrate a range of symptoms, clinical severity, and disease course in solid organ transplant recipients with COVID-19, including two hospitalized patients and two patients managed entirely in the outpatient setting.

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References

Huang J, Zheng K, George J, Gao H, Wei R, Yan H . Fatal outcome in a liver transplant recipient with COVID-19. Am J Transplant. 2020; 20(7):1907-1910. PMC: 7262021. DOI: 10.1111/ajt.15909. View

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J . Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020; 323(11):1061-1069. PMC: 7042881. DOI: 10.1001/jama.2020.1585. View

Yao X, Ye F, Zhang M, Cui C, Huang B, Niu P . In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020; 71(15):732-739. PMC: 7108130. DOI: 10.1093/cid/ciaa237. View

Gandolfini I, Delsante M, Fiaccadori E, Zaza G, Manenti L, Antoni A . COVID-19 in kidney transplant recipients. Am J Transplant. 2020; 20(7):1941-1943. PMC: 7228396. DOI: 10.1111/ajt.15891. View

Lai C, Shih T, Ko W, Tang H, Hsueh P . Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents. 2020; 55(3):105924. PMC: 7127800. DOI: 10.1016/j.ijantimicag.2020.105924. View

Ruan Q, Yang K, Wang W, Jiang L, Song J . Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020; 46(5):846-848. PMC: 7080116. DOI: 10.1007/s00134-020-05991-x. View

Zhang H, Chen Y, Yuan Q, Xia Q, Zeng X, Peng J . Identification of Kidney Transplant Recipients with Coronavirus Disease 2019. Eur Urol. 2020; 77(6):742-747. PMC: 7270372. DOI: 10.1016/j.eururo.2020.03.030. View

Bhoori S, Rossi R, Citterio D, Mazzaferro V . COVID-19 in long-term liver transplant patients: preliminary experience from an Italian transplant centre in Lombardy. Lancet Gastroenterol Hepatol. 2020; 5(6):532-533. PMC: 7146678. DOI: 10.1016/S2468-1253(20)30116-3. View

Ning L, Liu L, Li W, Liu H, Wang J, Yao Z . Novel coronavirus (SARS-CoV-2) infection in a renal transplant recipient: Case report. Am J Transplant. 2020; 20(7):1864-1868. PMC: 7262121. DOI: 10.1111/ajt.15897. View

10.

Qin J, Wang H, Qin X, Zhang P, Zhu L, Cai J . Perioperative Presentation of COVID-19 Disease in a Liver Transplant Recipient. Hepatology. 2020; 72(4):1491-1493. DOI: 10.1002/hep.31257. View

11.

Xu X, Wu X, Jiang X, Xu K, Ying L, Ma C . Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ. 2020; 368:m606. PMC: 7224340. DOI: 10.1136/bmj.m606. View

12.

Zhu L, Xu X, Ma K, Yang J, Guan H, Chen S . Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression. Am J Transplant. 2020; 20(7):1859-1863. PMC: 7228349. DOI: 10.1111/ajt.15869. View

13.

Li F, Cai J, Dong N . First cases of COVID-19 in heart transplantation from China. J Heart Lung Transplant. 2020; 39(5):496-497. PMC: 7156127. DOI: 10.1016/j.healun.2020.03.006. View

14.

Nalla A, Casto A, Huang M, Perchetti G, Sampoleo R, Shrestha L . Comparative Performance of SARS-CoV-2 Detection Assays Using Seven Different Primer-Probe Sets and One Assay Kit. J Clin Microbiol. 2020; 58(6). PMC: 7269385. DOI: 10.1128/JCM.00557-20. View

15.

Wang J, Li X, Cao G, Wu X, Wang Z, Yan T . COVID-19 in a Kidney Transplant Patient. Eur Urol. 2020; 77(6):769-770. PMC: 7271211. DOI: 10.1016/j.eururo.2020.03.036. View

16.

Conti P, Ronconi G, Caraffa A, Gallenga C, Ross R, Frydas I . Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020; 34(2):327-331. DOI: 10.23812/CONTI-E. View

17.

Chen J, Qi T, Liu L, Ling Y, Qian Z, Li T . Clinical progression of patients with COVID-19 in Shanghai, China. J Infect. 2020; 80(5):e1-e6. PMC: 7102530. DOI: 10.1016/j.jinf.2020.03.004. View

18.

Chen S, Yin Q, Shi H, Du D, Chang S, Ni L . A familial cluster, including a kidney transplant recipient, of Coronavirus Disease 2019 (COVID-19) in Wuhan, China. Am J Transplant. 2020; 20(7):1869-1874. PMC: 9800498. DOI: 10.1111/ajt.15903. View

19.

Marx D, Moulin B, Fafi-Kremer S, Benotmane I, Gautier G, Perrin P . First case of COVID-19 in a kidney transplant recipient treated with belatacept. Am J Transplant. 2020; 20(7):1944-1946. PMC: 7262359. DOI: 10.1111/ajt.15919. View

20.

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y . Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395(10223):507-513. PMC: 7135076. DOI: 10.1016/S0140-6736(20)30211-7. View