Gene Variants Have a Cross-diagnostic Influence on Psychosis and Treatment Improvement in Mood Disorders

Overview

Journal Clin Psychopharmacol Neurosci

Specialty Psychiatry

Date 2020 Apr 25

PMID 32329304

Citations 4

Authors

Marco Calabro

Laura Mandelli

Concetta Crisafulli

Marco Di Nicola

Roberto Colombo

Luigi Janiri

Soo-Jung Lee

Tae-Youn Jun

Sheng-Min Wang

Prakash S Masand

Ashwin A Patkar

Changsu Han

Chi-Un Pae

Alessandro Serretti

Affiliations

Soon will be listed here.

Abstract

Objective: Genetic variations in the gene encoding zinc finger protein 804A gene () have been associated with major depression and bipolar disorder. In this work we focused on the potential influence of variations on the risk of developing specific sub-phenotypes as well as the individual response to available treatments.

Methods: We used two samples of different ethnic origin: a Korean sample, composed by 242 patients diagnosed with major depression and 132 patients diagnosed with bipolar disorder and 326 healthy controls; an Italian sample composed 151 major depression subjects, 189 bipolar disorder subjects and 38 outpatients diagnosed for a primary anxiety disorder.

Results: Our analyses reported an association of rs1344706 with psychotic phenotype in the cross-diagnostic pooled sample (geno = 4.15 × 10, allelic = 1.06 × 10). In the cross-diagnosis Italian sample but not in the Korean one, rs7597593 was involved with depressive symptoms improvement after treatment (geno = 0.025, allelic = 0.007).

Conclusion: The present study evidenced the role of alterations in symptoms improvement after treatment. Both manic and depressive symptoms seem to be modulated by , though the latter was observed in the bipolar pooled sample only. The role of this factor is likely related to synaptic development and maintenance; however, further analyses will be needed to better understand the molecular mechanics involved with .

Citing Articles

ANK3 rs10994336 and ZNF804A rs7597593 polymorphisms: genetic interaction for emotional and behavioral symptoms of alcohol withdrawal syndrome.

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rs1344706 polymorphism of zinc finger protein 804a (ZNF804a) gene related to the integrity of white matter fiber bundle in schizophrenics.

Zhou J, Bao Q, Liang S, Guo H, Meng X, Zhang G Exp Ther Med. 2021; 22(1):778.

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Possible Modulatory Role of ARC Gene Variants in Mood Disorders.

Crisafulli C, Calabro M, Mandelli L, Wang S, Lee S, Han C Clin Psychopharmacol Neurosci. 2021; 19(1):46-52.

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Neuroplasticity, Neurotransmission and Brain-Related Genes in Major Depression and Bipolar Disorder: Focus on Treatment Outcomes in an Asiatic Sample.

Calabro M, Mandelli L, Crisafulli C, Lee S, Jun T, Wang S Adv Ther. 2018; 35(10):1656-1670.

PMID: 30178121 PMC: 6182627. DOI: 10.1007/s12325-018-0781-2.

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