DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment

Overview

Journal Front Genet

Date 2020 Apr 25

PMID 32328088

Citations 28

Authors

Hongming Zhu

He Zhu

Miao Tian

Dongying Wang

Jiaxing He

Tianmin Xu

Affiliations

Soon will be listed here.

Abstract

Recent discoveries have led to the development of novel ideas and techniques that have helped elucidate the correlation between epigenetics and tumor biology. Nowadays, the field of tumor genetics has evolved to include a new type of regulation by epigenetics. An increasing number of studies have demonstrated the importance of DNA methylation and hydroxymethylation in specific genes in the progression of cervical cancer. Determining the methylation and hydroxymethylation profiles of these genes will help in the early prevention and diagnosis, monitoring recurrence, prognosis, and treatment of patients with cervical cancer. In this review, we focus on the significance of aberrant DNA methylation and hydroxymethylation in cervical cancer and the use of these epigenetic signatures in clinical settings.

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References

Xu L, Xu J, Hu Z, Yang B, Wang L, Lin X . Quantitative DNA methylation analysis of paired box gene 1 and LIM homeobox transcription factor 1 α genes in cervical cancer. Oncol Lett. 2018; 15(4):4477-4484. PMC: 5835877. DOI: 10.3892/ol.2018.7872. View

Xie N, Zhou Y, Sun Q, Tang B . Novel Epigenetic Techniques Provided by the CRISPR/Cas9 System. Stem Cells Int. 2018; 2018:7834175. PMC: 6079388. DOI: 10.1155/2018/7834175. View

Wu Z, Zhao P . Epigenetic Alterations in Anesthesia-Induced Neurotoxicity in the Developing Brain. Front Physiol. 2018; 9:1024. PMC: 6079265. DOI: 10.3389/fphys.2018.01024. View

Sundaram M, Hussain A, Haque S, Raina R, Afroze N . Quercetin modifies 5'CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells. J Cell Biochem. 2019; 120(10):18357-18369. DOI: 10.1002/jcb.29147. View

Yin F, Wang N, Bi X, Yu X, Xu X, Wang Y . Serine/threonine kinases 31(STK31) may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer. Virol J. 2016; 13:60. PMC: 4820863. DOI: 10.1186/s12985-016-0515-5. View

Zhu H, Chen A, Li S, Tao X, Sheng B, Chetry M . Predictive role of galectin-1 and integrin α5β1 in cisplatin-based neoadjuvant chemotherapy of bulky squamous cervical cancer. Biosci Rep. 2017; 37(5). PMC: 5617914. DOI: 10.1042/BSR20170958. View

Meng Y, Liang H, Hu J, Liu S, Hao X, Wong M . PD-L1 Expression Correlates With Tumor Infiltrating Lymphocytes And Response To Neoadjuvant Chemotherapy In Cervical Cancer. J Cancer. 2018; 9(16):2938-2945. PMC: 6096364. DOI: 10.7150/jca.22532. View

Kan Y, Liou Y, Wang H, Chen C, Sung L, Chang C . PAX1 methylation as a potential biomarker for cervical cancer screening. Int J Gynecol Cancer. 2014; 24(5):928-34. DOI: 10.1097/IGC.0000000000000155. View

Kremer W, van Zummeren M, Novianti P, Richter K, Verlaat W, Snijders P . Detection of hypermethylated genes as markers for cervical screening in women living with HIV. J Int AIDS Soc. 2018; 21(8):e25165. PMC: 6088247. DOI: 10.1002/jia2.25165. View

10.

Leeman A, Ebisch R, Kasius A, Bosgraaf R, Jenkins D, van de Sandt M . Defining hrHPV genotypes in cervical intraepithelial neoplasia by laser capture microdissection supports reflex triage of self-samples using HPV16/18 and FAM19A4/miR124-2 methylation. Gynecol Oncol. 2018; 151(2):311-318. DOI: 10.1016/j.ygyno.2018.09.006. View

11.

Wang X, Cui N, Liu X, Ma J, Zhu Q, Guo S . Identification of Promoter Hypermethylation as a Biomarker for Intra-Epithelial Lesion and Cervical Cancer: A Meta-Analysis of Published Studies, TCGA, and GEO Datasets. Front Genet. 2018; 9:258. PMC: 6056635. DOI: 10.3389/fgene.2018.00258. View

12.

Chen Y, Cui Z, Xiao Z, Hu M, Jiang C, Lin Y . PAX1 and SOX1 methylation as an initial screening method for cervical cancer: a meta-analysis of individual studies in Asians. Ann Transl Med. 2016; 4(19):365. PMC: 5075846. DOI: 10.21037/atm.2016.09.30. View

13.

Kong L, Du W, Wang L, Yang Z, Zhang H . PAX1 Methylation Hallmarks Promising Accuracy for Cervical Cancer Screening in Asians: Results from a Meta-Analysis. Clin Lab. 2015; 61(10):1471-9. DOI: 10.7754/clin.lab.2015.150232. View

14.

Wang J, Su Y, Tian Y, Ding Y, Wang X . Characterization of DNA hydroxymethylation profile in cervical cancer. Artif Cells Nanomed Biotechnol. 2019; 47(1):2706-2714. DOI: 10.1080/21691401.2019.1634578. View

15.

Yadav P, Masroor M, Nandi K, Kaza R, Jain S, Khurana N . Promoter Methylation of BRCA1, DAPK1 and RASSF1A is Associated with Increased Mortality among Indian Women with Breast Cancer. Asian Pac J Cancer Prev. 2018; 19(2):443-448. PMC: 5980932. DOI: 10.22034/APJCP.2018.19.2.443. View

16.

Li M, Gao F, Xia Y, Tang Y, Zhao W, Jin C . Filtrating colorectal cancer associated genes by integrated analyses of global DNA methylation and hydroxymethylation in cancer and normal tissue. Sci Rep. 2016; 6:31826. PMC: 4992821. DOI: 10.1038/srep31826. View

17.

Tian Y, Wu N, Liou Y, Yeh C, Cao L, Kang Y . Utility of gene methylation analysis, cytological examination, and HPV-16/18 genotyping in triage of high-risk human papilloma virus-positive women. Oncotarget. 2017; 8(37):62274-62285. PMC: 5617504. DOI: 10.18632/oncotarget.19459. View

18.

Rong G, Zhang M, Xia W, Li D, Miao J, Wang H . Plasma CADM1 promoter hypermethylation and D-dimer as novel metastasis predictors of cervical cancer. J Obstet Gynaecol Res. 2019; 45(7):1251-1259. DOI: 10.1111/jog.13966. View

19.

Verlaat W, van Leeuwen R, Novianti P, Schuuring E, Meijer C, van der Zee A . Host-cell DNA methylation patterns during high-risk HPV-induced carcinogenesis reveal a heterogeneous nature of cervical pre-cancer. Epigenetics. 2018; 13(7):769-778. PMC: 6224221. DOI: 10.1080/15592294.2018.1507197. View

20.

Neri F, Dettori D, Incarnato D, Krepelova A, Rapelli S, Maldotti M . TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway. Oncogene. 2014; 34(32):4168-76. DOI: 10.1038/onc.2014.356. View