Revisiting the Ghrelin Changes Following Bariatric and Metabolic Surgery

Overview

Journal Obes Surg

Date 2020 Apr 24

PMID 32323063

Citations 15

Authors

Carlota Tuero

Victor Valenti

Fernando Rotellar

Manuel F Landecho

Javier A Cienfuegos

Gema Fruhbeck

Affiliations

Soon will be listed here.

Abstract

Since the description of ghrelin in 1999, several studies have dug into the effects of this hormone and its relationship with bariatric surgery. While some aspects are still unresolved, a clear connection between ghrelin and the changes after metabolic surgery have been established. Besides weight loss, a significant amelioration in obesity-related comorbidities following surgery has also been reported. These changes in patients occur in the early postoperative period, before the weight loss appears, so that amelioration may be mainly due to hormonal changes. The purpose of this review is to go through the current body of knowledge of ghrelin's physiology, as well as to update and clarify the changes that take place in ghrelin concentrations following bariatric/metabolic surgery together with their potential consolidation to outcomes.

Citing Articles

Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Suboptimal Initial Clinical Response and Weight Gain Recurrence After Bariatric Surgery: a Systematic Review and Meta-analysis.

Nie Y, Zhang Y, Liu B, Meng H Obes Surg. 2025; 35(3):808-822.

PMID: 39948306 DOI: 10.1007/s11695-025-07733-8.

Changes in Fat Mass Index and Fat-Free Mass Index Vary Significantly by Age and Sex of the Patient, and by Type of Bariatric Surgery.

Hassan Zadeh M, Fatemi S, Rezvani R, Farsani G, Pazouki A, Zamaninour N Obes Surg. 2024; 34(10):3781-3789.

PMID: 39160368 DOI: 10.1007/s11695-024-07465-1.

Correlation analysis between the changes in plasma ghrelin level and weight loss after sleeve gastrectomy combined with fundoplication.

Li X, Aili A, Aipire A, Maimaitiyusupu P, Maimaitiming M, Abudureyimu K BMC Surg. 2024; 24(1):176.

PMID: 38840104 PMC: 11151524. DOI: 10.1186/s12893-024-02468-2.

The circulating and central endocannabinoid system in obesity and weight loss.

Mattelaer N, Van der Schueren B, Van Oudenhove L, Weltens N, Vangoitsenhoven R Int J Obes (Lond). 2024; 48(10):1363-1382.

PMID: 38834796 DOI: 10.1038/s41366-024-01553-z.

Analysis of influencing factors and construction of prediction model for postoperative nausea and vomiting in patients undergoing laparoscopic sleeve gastrectomy: a single-center retrospective cohort study.

Liao B, Liao W, Wu X, Liu S, Li Y, Qin R BMC Anesthesiol. 2024; 24(1):131.

PMID: 38580903 PMC: 10996113. DOI: 10.1186/s12871-024-02502-z.