Effects of Compound Active Peptides on Protecting Liver and Intestinal Epithelial Cells from Damages and Preventing Hyperglycemia

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2020 Apr 23

PMID 32318237

Citations 2

Authors

Xiaoxiang Xu

Yingjia Wei

Mian Khaqan Shah

Xiaoyu Wang

Junting Lin

Peng Wan

Li Cui

Qingqiang Yin

Affiliations

Soon will be listed here.

Abstract

Active peptides have good effectiveness in controlling or preventing many diseases. Compound active peptides (CAP) obtained from animal, plant, and sea food proteins were used in this study to explore their effects on antioxidation, anti-inflammation, and antihyperglycemia and . The results demonstrated that 10 g/mL CAP could increase cell viability ( < 0.05) and decrease reactive oxygen species (ROS) levels and cell apoptosis ( < 0.05) when WRL68 cells were induced by HO for 6 h. Moreover, incubation with 20 g/mL CAP for 6 h significantly increased cell viability and Bcl-2 expression level ( < 0.05) and decreased expression levels of IL-6, IL-8, TNF-, Bax, and Caspase 3 and the ratio of Bax/Bcl-2 ( < 0.05) when swine jejunal epithelial cells (IPEC-J2) were induced by deoxynivalenol (DON). In addition, adding CAP individually or combined with Liuweidihuang pills (LDP, Chinese medicine) and low-dose glibenclamide could lower blood glucose levels in alloxan-induced hyperglycemic model mice. These results suggested that CAP was probably a beneficial ingredient for alleviating HO-induced oxidative stress and DON-induced cell inflammation and apoptosis and preventing hyperglycemia.

Citing Articles

Stevioside Improves Antioxidant Capacity and Intestinal Barrier Function while Attenuating Inflammation and Apoptosis by Regulating the NF-κB/MAPK Pathways in Diquat-Induced Oxidative Stress of IPEC-J2 Cells.

Xu Q, Liu M, Chao X, Zhang C, Yang H, Chen J Antioxidants (Basel). 2023; 12(5).

PMID: 37237936 PMC: 10215602. DOI: 10.3390/antiox12051070.

Hypoxia, oxidative stress, and immune evasion: a trinity of the trichothecenes T-2 toxin and deoxynivalenol (DON).

You L, Zhao Y, Kuca K, Wang X, Oleksak P, Chrienova Z Arch Toxicol. 2021; 95(6):1899-1915.

PMID: 33765170 DOI: 10.1007/s00204-021-03030-2.

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