A Comparison of the Corneal Biomechanics in Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma, and Healthy Controls Using Corvis® Scheimpflug Technology

Overview

Journal Indian J Ophthalmol

Specialty Ophthalmology

Date 2020 Apr 23

PMID 32317447

Citations 4

Authors

Zia S Pradhan

Sujit Deshmukh

Shivani Dixit

Praveena Gudetti

Sathi Devi

Carroll A B Webers

Harsha L Rao

Affiliations

Soon will be listed here.

Abstract

Purpose: To compare the corneal biomechanical parameters among pseudoexfoliation syndrome (PXF), pseudoexfoliation glaucoma (PXG), and healthy controls using Corvis Scheimpflug Technology (ST).

Methods: A prospective, cross-sectional study of 141 treatment-naïve eyes that underwent Corvis ST was conducted. These included 42 eyes with PXF, 17 eyes of PXF with ocular hypertension (PXF + OHT) defined as intraocular pressure (IOP)> 21 mmHg without disc/field changes, 37 eyes with PXG, and 45 healthy controls. Corneal biomechanical parameters, which included corneal velocities, length of corneal applanated surface, deformation amplitude (DA), peak distance, and radius of curvature, were compared among the groups using analysis of variance models.

Results: The four groups were demographically similar. The mean IOP was lower in the controls (15.6 ± 3 mmHg) and PXF group (16.0 ± 3 mmHg) compared to the other two groups (>24 mmHg). Corneal pachymetry was similar across the four groups. Mean DA was significantly lower (P < 0.0001) in the PXG group (0.91 ± 0.18 mm) and the PXF + OHT group (0.94 ± 0.13 mm) when compared to the PXF (1.10 ± 0.11 mm) and control groups (1.12 ± 0.14 mm). Corneal velocities were also found to be statistically significantly lower in PXG and PXF + OHT compared to the PXF and control groups. However, after adjusting for age and IOP, there was no difference in any of the biomechanical parameters among the four groups.

Conclusion: Corneal biomechanical parameters measured on Corvis ST are not different between healthy controls and eyes with PXF and PXG. Since PXG is a high-pressure glaucoma, corneal biomechanics may not play an important role in its diagnosis and pathogenesis.

Citing Articles

Factors affecting corneal deformation amplitude measured by Corvis ST in eyes with open-angle glaucoma.

Pradhan Z, Sreenivasaiah S, Deshmukh S, Mangala L, Shroff S, Devi S Indian J Ophthalmol. 2023; 72(4):533-537.

PMID: 38099366 PMC: 11149506. DOI: 10.4103/IJO.IJO_822_23.

Corneal Biomechanical Measures for Glaucoma: A Clinical Approach.

Elhusseiny A, Scarcelli G, Saeedi O Bioengineering (Basel). 2023; 10(10).

PMID: 37892838 PMC: 10604716. DOI: 10.3390/bioengineering10101108.

Biomechanical analysis of ocular diseases and its in vitro study methods.

Zhao Y, Hu G, Yan Y, Wang Z, Liu X, Shi H Biomed Eng Online. 2022; 21(1):49.

PMID: 35870978 PMC: 9308301. DOI: 10.1186/s12938-022-01019-1.

A comparison of the corneal biomechanics in pseudoexfoliation glaucoma, primary open-angle glaucoma and healthy controls using Corvis ST.

Pradhan Z, Deshmukh S, Dixit S, Sreenivasaiah S, Shroff S, Devi S PLoS One. 2020; 15(10):e0241296.

PMID: 33104764 PMC: 7588080. DOI: 10.1371/journal.pone.0241296.

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