Swelling Characteristics and Biocompatibility of Ionic Liquid Based Hydrogels for Biomedical Applications

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2020 Apr 21

PMID 32310981

Citations 12

Authors

Johanna Claus

Andreas Brietzke

Celina Lehnert

Stefan Oschatz

Niels Grabow

Udo Kragl

Affiliations

Soon will be listed here.

Abstract

Polymers are commonly used in medical device manufacturing, e.g. for drug delivery systems, bone substitutes and stent coatings. Especially hydrogels exhibit very promising properties in this field. Hence, the development of new hydrogel systems for customized application is of great interest, especially regarding the swelling behavior and mechanical properties as well as the biocompatibility. The aim of this work was the preparation and investigation of various polyelectrolyte and poly-ionic liquid based hydrogels accessible by radical polymerization. The obtained polymers were covalently crosslinked with N,N'-methylenebisacrylamide (MBAA) or different lengths of poly(ethyleneglycol)diacrylate (PEGDA). The effect of different crosslinker-to-monomer ratios has been examined. In addition to the compression curves and the maximum degree of swelling, the biocompatibility with L929 mouse fibroblasts of these materials was determined in direct cell seeding experiments and the outcome for the different hydrogels was compared.

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