Discoveries Interview: Professor Bhanu P. Jena on the Discovery of the Porosome, the Universal Machinery for Cellular Secretion

Overview

Journal Discoveries (Craiova)

Specialty General Medicine

Date 2020 Apr 21

PMID 32309555

Citations 2

Affiliations

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Citing Articles

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Cell secretion and membrane fusion: highly significant phenomena in the life of a cell.

Leabu M, Nicolson G Discoveries (Craiova). 2020; 2(3):e30.

PMID: 32309557 PMC: 6941589. DOI: 10.15190/d.2014.22.

References

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Jeremic A, Kelly M, Cho S, Stromer M, Jena B . Reconstituted fusion pore. Biophys J. 2003; 85(3):2035-43. PMC: 1303375. DOI: 10.1016/S0006-3495(03)74631-1. View

Jena B . Secretion machinery at the cell plasma membrane. Curr Opin Struct Biol. 2007; 17(4):437-43. PMC: 2075359. DOI: 10.1016/j.sbi.2007.07.002. View

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Cho S, Jeftinija K, Glavaski A, Jeftinija S, Jena B, Anderson L . Structure and dynamics of the fusion pores in live GH-secreting cells revealed using atomic force microscopy. Endocrinology. 2002; 143(3):1144-8. DOI: 10.1210/endo.143.3.8773. View

Almers W, Tse F . Transmitter release from synapses: does a preassembled fusion pore initiate exocytosis?. Neuron. 1990; 4(6):813-8. DOI: 10.1016/0896-6273(90)90134-2. View

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Kelly M, Cho W, Jeremic A, Abu-Hamdah R, Jena B . Vesicle swelling regulates content expulsion during secretion. Cell Biol Int. 2004; 28(10):709-16. DOI: 10.1016/j.cellbi.2004.07.005. View

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Jena B, Cho S, Jeremic A, Stromer M, Abu-Hamdah R . Structure and composition of the fusion pore. Biophys J. 2003; 84(2 Pt 1):1337-43. PMC: 1302710. DOI: 10.1016/S0006-3495(03)74949-2. View

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Lee J, Jeremic A, Shin L, Cho W, Chen X, Jena B . Neuronal porosome proteome: Molecular dynamics and architecture. J Proteomics. 2012; 75(13):3952-62. PMC: 4580231. DOI: 10.1016/j.jprot.2012.05.017. View

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Schneider S, Sritharan K, Geibel J, Oberleithner H, Jena B . Surface dynamics in living acinar cells imaged by atomic force microscopy: identification of plasma membrane structures involved in exocytosis. Proc Natl Acad Sci U S A. 1997; 94(1):316-21. PMC: 19328. DOI: 10.1073/pnas.94.1.316. View

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Jena B . Porosome: the secretory portal in cells. Biochemistry. 2009; 48(19):4009-18. PMC: 4580239. DOI: 10.1021/bi9002698. View

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Kovari L, Brunzelle J, Lewis K, Cho W, Lee J, Taatjes D . X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release. Micron. 2013; 56:37-43. DOI: 10.1016/j.micron.2013.10.002. View