Dietary Countermeasure Mitigates Simulated Spaceflight-induced Osteopenia in Mice

Overview

Journal Sci Rep

Specialty Science

Date 2020 Apr 18

PMID 32300161

Citations 7

Authors

Sonette Steczina

Candice G T Tahimic

Megan Pendleton

Ons MSaad

Moniece Lowe

Joshua S Alwood

Bernard P Halloran

Ruth K Globus

Ann-Sofie Schreurs

Affiliations

Soon will be listed here.

Abstract

Spaceflight is a unique environment that includes at least two factors which can negatively impact skeletal health: microgravity and ionizing radiation. We have previously shown that a diet supplemented with dried plum powder (DP) prevented radiation-induced bone loss in mice. In this study, we investigated the capacity of the DP diet to prevent bone loss in mice following exposure to simulated spaceflight, combining microgravity (by hindlimb unloading) and radiation exposure. The DP diet was effective at preventing most decrements in bone micro-architectural and mechanical properties due to hindlimb unloading alone and simulated spaceflight. Furthermore, we show that the DP diet can protect osteoprogenitors from impairments resulting from simulated microgravity. Based on our findings, a dietary supplementation with DP could be an effective countermeasure against the skeletal deficits observed in astronauts during spaceflight.

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