Release of Gonadotrophin-releasing Hormone (Gn-RH) from Isolated, Perifused Medial-basal Hypothalamus by Melatonin

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 1977 Jun 1

PMID 322999

Citations 5

Authors

L W Kao

J Weisz

Affiliations

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Abstract

Basal release of Gn-RH from perifused medial-basal hypothalami of rats was at or below levels detectable by radioimmunoassay. Infusion of norepinephrine, dopamine, acetylcholine or serotonin (0.1-10 mM) as 10-20 min pulses was not associated with a detectable increase of Gn-RH in the effluent. However, 10-20 min pulses of melatonin (0.1-1.0 mM) consistently caused release of Gn-RH.

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