High Density Lipoproteins: Metabolism, Function, and Therapeutic Potential

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2020 Apr 17

PMID 32296714

Citations 38

Authors

Anne Jomard

Elena Osto

Affiliations

Soon will be listed here.

Abstract

High Density Lipoproteins (HDLs) have long been considered as "good cholesterol," beneficial to the whole body and, in particular, to cardio-vascular health. However, HDLs are complex particles that undergoes dynamic remodeling through interactions with various enzymes and tissues throughout their life cycle, making the complete understanding of its functions and roles more complicated than initially expected. In this review, we explore the novel understanding of HDLs' behavior in health and disease as a multifaceted class of lipoprotein, with different size subclasses, molecular composition, receptor interactions, and functionality. Further, we report on emergent HDL-based therapeutics tested in small and larger scale clinical trials and their mixed successes.

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