Hydroxychloroquine and COVID-19

Overview

Journal Postgrad Med J

Publisher Oxford University Press

Specialty General Medicine

Date 2020 Apr 17

PMID 32295814

Citations 82

Authors

Neeraj Sinha

Galit Balayla

Affiliations

Soon will be listed here.

Abstract

Hydroxychloroquine and chloroquine are medications that have been used for a long time. Their most common use is for the treatment and prophylaxis of malaria. However, these antimalarial drugs are known to also have anti-inflammatory and antiviral effects and are used for several chronic diseases such as systemic lupus erythematosus with low adverse effects. The antiviral action of hydroxychloroquine and chloroquine has been a point of interest to different researchers due to its mechanism of action. Several in vitro studies have proven their effectiveness on severe acute respiratory syndrome virus and currently both in vitro and in vivo studies have been conducted on 2019 novel coronavirus (covid-19). The purpose of this article is to review the history and mechanism of actions of these drugs and the potential use they can have on the current covid-19 pandemic.

Citing Articles

Efficacy of Ivermectin, Chloroquine/Hydroxychloroquine, and Azithromycin in Managing COVID-19: A Systematic Review of Phase III Clinical Trials.

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PMID: 39457519 PMC: 11505156. DOI: 10.3390/biomedicines12102206.

Adverse drug reactions associated with COVID-19 management.

Chavda V, Dodiya P, Apostolopoulos V Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(10):7353-7376.

PMID: 38743117 DOI: 10.1007/s00210-024-03137-0.

Quality-by-design ecofriendly potentiometric sensor for rapid monitoring of hydroxychloroquine purity in the presence of toxic impurities.

Draz M, Edrees F, Mohamed H, Hammad S, Saad A Sci Rep. 2024; 14(1):6869.

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Reflections on Participation in a Trial on Hydroxychloroquine as Prevention for COVID-19 among Health Workers in Niger.

Kabore Y, Vatrinet R, Guindo O, Moussa S, Schilling W, Grais R Am J Trop Med Hyg. 2023; 109(3):511-514.

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Janicki P, Singh A, Sharma A, Ruiz-Velasco V Physiol Rep. 2023; 11(14):e15760.

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References

Tanenbaum L, Tuffanelli D . Antimalarial agents. Chloroquine, hydroxychloroquine, and quinacrine. Arch Dermatol. 1980; 116(5):587-91. DOI: 10.1001/archderm.116.5.587. View

Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M . Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020; 30(3):269-271. PMC: 7054408. DOI: 10.1038/s41422-020-0282-0. View

Shukla A, Wagle Shukla A . Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues. Drugs Context. 2019; 8. PMC: 6905642. DOI: 10.7573/dic.2019-9-1. View

Gao J, Tian Z, Yang X . Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends. 2020; 14(1):72-73. DOI: 10.5582/bst.2020.01047. View

Lan T, Chang L, Wu L, Yuan Y . IL-6 Plays a Crucial Role in HBV Infection. J Clin Transl Hepatol. 2016; 3(4):271-6. PMC: 4721895. DOI: 10.14218/JCTH.2015.00024. View

Mates M, Nesher G, Zevin S . [Quinines--past and present]. Harefuah. 2007; 146(7):560-2, 572. View

Clark P, Casas E, Tugwell P, Medina C, Gheno C, Tenorio G . Hydroxychloroquine compared with placebo in rheumatoid arthritis. A randomized controlled trial. Ann Intern Med. 1993; 119(11):1067-71. DOI: 10.7326/0003-4819-119-11-199312010-00002. View

Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z . SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. N Engl J Med. 2020; 382(12):1177-1179. PMC: 7121626. DOI: 10.1056/NEJMc2001737. View

Vincent M, Bergeron E, Benjannet S, Erickson B, Rollin P, Ksiazek T . Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol J. 2005; 2:69. PMC: 1232869. DOI: 10.1186/1743-422X-2-69. View

10.

van den Borne B, Dijkmans B, de Rooij H, le Cessie S, Verweij C . Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells. J Rheumatol. 1997; 24(1):55-60. View

11.

Velazquez-Salinas L, Verdugo-Rodriguez A, Rodriguez L, Borca M . The Role of Interleukin 6 During Viral Infections. Front Microbiol. 2019; 10:1057. PMC: 6524401. DOI: 10.3389/fmicb.2019.01057. View

12.

Keyaerts E, Vijgen L, Maes P, Neyts J, Van Ranst M . In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine. Biochem Biophys Res Commun. 2004; 323(1):264-8. PMC: 7092815. DOI: 10.1016/j.bbrc.2004.08.085. View

13.

Lester R, BURNHAM T, FINE G, Murray K . Immunologic concepts of light reactions in lupus erythematosus and polymorphous light eruptions. I. The mechanism of action of hydroxychloroquine. Arch Dermatol. 1967; 96(1):1-10. View

14.

Gautret P, Lagier J, Parola P, Hoang V, Meddeb L, Mailhe M . RETRACTED: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020; 56(1):105949. PMC: 7102549. DOI: 10.1016/j.ijantimicag.2020.105949. View

15.

Geser A, Brubaker G, Draper C . Effect of a malaria suppression program on the incidence of African Burkitt's lymphoma. Am J Epidemiol. 1989; 129(4):740-52. DOI: 10.1093/oxfordjournals.aje.a115189. View

16.

Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798):270-273. PMC: 7095418. DOI: 10.1038/s41586-020-2012-7. View

17.

Loffler B, Bohn E, Hesse B, Kunze H . Effects of antimalarial drugs on phospholipase A and lysophospholipase activities in plasma membrane, mitochondrial, microsomal and cytosolic subcellular fractions of rat liver. Biochim Biophys Acta. 1985; 835(3):448-55. DOI: 10.1016/0005-2760(85)90114-6. View

18.

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H . Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020; 395(10224):565-574. PMC: 7159086. DOI: 10.1016/S0140-6736(20)30251-8. View

19.

Page F . Treatment of lupus erythematosus with mepacrine. Lancet. 1951; 2(6687):755-8. DOI: 10.1016/s0140-6736(51)91643-1. View

20.

Cohen S, Yielding K . SPECTROPHOTOMETRIC STUDIES OF THE INTERACTION OF CHLOROQUINE WITH DEOXYRIBONUCLEIC ACID. J Biol Chem. 1965; 240:3123-31. View