Blastocyst-stage Embryos Provide Better Frozen-thawed Embryo Transfer Outcomes for Young Patients with Previous Fresh Embryo Transfer Failure

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2020 Apr 16

PMID 32294624

Citations 4

Authors

Lanlan Fang

Jingyan He

Yang Yan

Qiongqiong Jia

Yiping Yu

Ruizhe Zhang

Jung-Chien Cheng

Ying-Pu Sun

Affiliations

Soon will be listed here.

Abstract

Older patients or patients with a reduced ovarian response have a low number of embryos, which limits the opportunity for embryo selection. However, for young patients undergoing frozen-thawed embryo transfer (ET), it remains unclear whether embryo stage affects pregnancy outcomes. In the present study, a total of 2952 patients undergoing their first frozen-thawed ET were divided into two groups: patients who had experienced one failed fresh ET (Group A) and patients who had not received fresh ET because of the high risk of ovarian hyperstimulation syndrome (OHSS) (Group B). Our results show that Group B patients had a significantly higher clinical pregnancy rate (CPR) and live birth rate (LBR) than Group A patients. However, Group A patients who underwent blastocyst-stage frozen-thawed ET had a significantly higher CPR and LBR and a lower ectopic pregnancy rate (ePR) than did those who underwent cleavage-stage frozen-thawed ET. In Group B, CPR, ePR, LBR and spontaneous abortion rate (sAR) were similar with blastocyst-stage and cleavage-stage frozen-thawed ET. These results suggest that blastocyst-stage frozen-thawed ET is more appropriate for young patients who had previously undergone one failed fresh ET cycle.

Citing Articles

Does The Culture of Post-Thawed Cleavage-Stage Embryos to Blastocysts Improve Infertility Treatment Outcomes of Frozen-Thawed Embryo Transfer Cycles? A Randomised Clinical Trial.

Madani T, Jahangiri N, Yahyaei A, Vesali S, Zarei M, Eftekhari-Yazdi P Int J Fertil Steril. 2024; 18(2):146-152.

PMID: 38368518 PMC: 10875310. DOI: 10.22074/ijfs.2023.560780.1357.

Parent Joint AB Blood Group Is Associated With Clinical Outcomes of Fertilization and Intracytoplasmic Sperm Injection Treatment in Chinese Women.

Bao X, Zhao F, Shi H, Bu Z, Liang Y, Sun Y Front Med (Lausanne). 2022; 9:813781.

PMID: 35602516 PMC: 9115895. DOI: 10.3389/fmed.2022.813781.

Case Report: Twin Pregnancy Gives Birth to a Girl with Partial Trisomy 21 Mosaicism after Fertilization and Embryo Transfer.

Guo Z, Kang B, Wu D, Xiao H, Hao L, Hao B Front Genet. 2022; 12:740415.

PMID: 35185999 PMC: 8850307. DOI: 10.3389/fgene.2021.740415.

Ovarian Hyperstimulation Syndrome Is Associated with a High Secondary Sex Ratio in Fresh IVF Cycles with Cleavage-Stage Embryo Transfer: Results for a Cohort Study.

Jia Q, Fang L, Wang Z, Wu Z, Yan Y, Liu B Reprod Sci. 2021; 28(12):3341-3351.

PMID: 34081318 DOI: 10.1007/s43032-021-00637-9.

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