Antifouling Polymer Brushes Via Oxygen-Tolerant Surface-Initiated PET-RAFT

Overview

Journal Langmuir

Publisher American Chemical Society

Specialty Chemistry

Date 2020 Apr 16

PMID 32293894

Citations 15

Authors

Andriy R Kuzmyn

Ai T Nguyen

Lucas W Teunissen

Han Zuilhof

Jacob Baggerman

Affiliations

Soon will be listed here.

Abstract

This work presents a new method for the synthesis of antifouling polymer brushes using surface-initiated photoinduced electron transfer-reversible addition-fragmentation chain-transfer polymerization with eosin Y and triethanolamine as catalysts. This method proceeds in an aqueous environment under atmospheric conditions without any prior degassing and without the use of heavy metal catalysts. The versatility of the method is shown by using three chemically different monomers: oligo(ethylene glycol) methacrylate, -(2-hydroxypropyl)methacrylamide, and carboxybetaine methacrylamide. In addition, the light-triggered nature of the polymerization allows the creation of complex three-dimensional structures. The composition and topological structuring of the brushes are confirmed by X-ray photoelectron spectroscopy and atomic force microscopy. The kinetics of the polymerizations are followed by measuring the layer thickness with ellipsometry. The polymer brushes demonstrate excellent antifouling properties when exposed to single-protein solutions and complex biological matrices such as diluted bovine serum. This method thus presents a new simple approach for the manufacturing of antifouling coatings for biomedical and biotechnological applications.

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References

Giesbers M, Marcelis A, Zuilhof H . Simulation of XPS C1s spectra of organic monolayers by quantum chemical methods. Langmuir. 2013; 29(15):4782-8. DOI: 10.1021/la400445s. View

Rana D, Matsuura T . Surface modifications for antifouling membranes. Chem Rev. 2010; 110(4):2448-71. DOI: 10.1021/cr800208y. View

Zoppe J, Ataman N, Mocny P, Wang J, Moraes J, Klok H . Surface-Initiated Controlled Radical Polymerization: State-of-the-Art, Opportunities, and Challenges in Surface and Interface Engineering with Polymer Brushes. Chem Rev. 2017; 117(3):1105-1318. DOI: 10.1021/acs.chemrev.6b00314. View

Yang J, Kopecek J . Design of smart HPMA copolymer-based nanomedicines. J Control Release. 2015; 240:9-23. PMC: 4819016. DOI: 10.1016/j.jconrel.2015.10.003. View

Jiang S, Cao Z . Ultralow-fouling, functionalizable, and hydrolyzable zwitterionic materials and their derivatives for biological applications. Adv Mater. 2010; 22(9):920-32. DOI: 10.1002/adma.200901407. View

Vaisocherova H, Sevcu V, Adam P, Spackova B, Hegnerova K, de Los Santos Pereira A . Functionalized ultra-low fouling carboxy- and hydroxy-functional surface platforms: functionalization capacity, biorecognition capability and resistance to fouling from undiluted biological media. Biosens Bioelectron. 2013; 51:150-7. DOI: 10.1016/j.bios.2013.07.015. View

Matsuda T, Ohya S . Photoiniferter-based thermoresponsive graft architecture with albumin covalently fixed at growing graft chain end. Langmuir. 2005; 21(21):9660-5. DOI: 10.1021/la050221o. View

Matyjaszewski K . Advanced Materials by Atom Transfer Radical Polymerization. Adv Mater. 2018; 30(23):e1706441. DOI: 10.1002/adma.201706441. View

Rodriguez-Emmenegger C, Brynda E, Riedel T, Houska M, Subr V, Alles A . Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces. Macromol Rapid Commun. 2011; 32(13):952-7. DOI: 10.1002/marc.201100189. View

10.

Li M, Fromel M, Ranaweera D, Rocha S, Boyer C, Pester C . SI-PET-RAFT: Surface-Initiated Photoinduced Electron Transfer-Reversible Addition-Fragmentation Chain Transfer Polymerization. ACS Macro Lett. 2022; 8(4):374-380. DOI: 10.1021/acsmacrolett.9b00089. View

11.

Nguyen A, Baggerman J, Paulusse J, Zuilhof H, van Rijn C . Bioconjugation of protein-repellent zwitterionic polymer brushes grafted from silicon nitride. Langmuir. 2011; 28(1):604-10. DOI: 10.1021/la2031363. View

12.

Laschewsky A, Rosenhahn A . Molecular Design of Zwitterionic Polymer Interfaces: Searching for the Difference. Langmuir. 2018; 35(5):1056-1071. DOI: 10.1021/acs.langmuir.8b01789. View

13.

Homola J . Surface plasmon resonance sensors for detection of chemical and biological species. Chem Rev. 2008; 108(2):462-93. DOI: 10.1021/cr068107d. View

14.

Nguyen A, Baggerman J, Paulusse J, van Rijn C, Zuilhof H . Stable protein-repellent zwitterionic polymer brushes grafted from silicon nitride. Langmuir. 2011; 27(6):2587-94. DOI: 10.1021/la104657c. View

15.

Andree K, Barradas A, Nguyen A, Mentink A, Stojanovic I, Baggerman J . Capture of Tumor Cells on Anti-EpCAM-Functionalized Poly(acrylic acid)-Coated Surfaces. ACS Appl Mater Interfaces. 2016; 8(23):14349-56. DOI: 10.1021/acsami.6b01241. View

16.

Gahtory D, Sen R, Kuzmyn A, Escorihuela J, Zuilhof H . Strain-Promoted Cycloaddition of Cyclopropenes with o-Quinones: A Rapid Click Reaction. Angew Chem Int Ed Engl. 2018; 57(32):10118-10122. PMC: 6099469. DOI: 10.1002/anie.201800937. View

17.

Thissen H, Gengenbach T, du Toit R, Sweeney D, Kingshott P, Griesser H . Clinical observations of biofouling on PEO coated silicone hydrogel contact lenses. Biomaterials. 2010; 31(21):5510-9. DOI: 10.1016/j.biomaterials.2010.03.040. View

18.

Vaisocherova-Lisalova H, Surman F, Visova I, Vala M, Springer T, Ermini M . Copolymer Brush-Based Ultralow-Fouling Biorecognition Surface Platform for Food Safety. Anal Chem. 2016; 88(21):10533-10539. DOI: 10.1021/acs.analchem.6b02617. View

19.

Lueckerath T, Strauch T, Koynov K, Barner-Kowollik C, Ng D, Weil T . DNA-Polymer Conjugates by Photoinduced RAFT Polymerization. Biomacromolecules. 2018; 20(1):212-221. DOI: 10.1021/acs.biomac.8b01328. View

20.

Rodriguez-Emmenegger C, Avramenko O, Brynda E, Skvor J, Alles A . Poly(HEMA) brushes emerging as a new platform for direct detection of food pathogen in milk samples. Biosens Bioelectron. 2011; 26(11):4545-51. DOI: 10.1016/j.bios.2011.05.021. View