Evaluation of the Renal Injury from Gold Salts and Nonsteroidal Anti-inflammatory Drugs in Patients with Rheumatoid Arthritis

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 1988 Sep 1

PMID 3229079

Authors

N Giordano

E Frati

A Fioravanti

A Taddeo

G Morozzi

R Marcolongo

Affiliations

Soon will be listed here.

Abstract

The urinary excretion of proteins, N-acetyl-3-glucosaminidase and leucine aminopeptidase, was measured in 50 patients with rheumatoid arthritis (RA), of whom 20 subjects were on nonsteroidal anti-inflammatory drugs (NSAIDs) and 30 on gold salts. No pathological changes of the above-mentioned urinary parameters have been observed in the group of RA patients, in comparison with control subjects and patients suffering from osteoarthritis treated with NSAIDs.

References

Merle L, Reidenberg M, Camacho M, Jones B, Drayer D . Renal injury in patients with rheumatoid arthritis treated with gold. Clin Pharmacol Ther. 1980; 28(2):216-22. DOI: 10.1038/clpt.1980.153. View

Reeves W, Foley R, Weinman E . Renal dysfunction from nonsteroidal anti-inflammatory drugs. Arch Intern Med. 1984; 144(10):1943-4. DOI: 10.1001/archinte.144.10.1943. View

Clemenzia G, LATERZA G, Russo G, Santini P, Scibinetti F, Gentile V . [Normal values of the urinary activity of 4 enzymes]. Minerva Med. 1984; 75(43):2591-6. View

Fox D, Jick H . Nonsteroidal anti-inflammatory drugs and renal disease. JAMA. 1984; 251(10):1299-300. View

. Gold Therapy in Rheumatoid Arthritis: Final Report of a Multicentre Controlled Trial. Ann Rheum Dis. 1961; 20(4):315-34. PMC: 1007231. DOI: 10.1136/ard.20.4.315. View

Galler M, Folkert V, Schlondorff D . Reversible acute renal insufficiency and hyperkalemia following indomethacin therapy. JAMA. 1981; 246(2):154-5. View

Dunn M . Nonsteroidal antiinflammatory drugs and renal function. Annu Rev Med. 1984; 35:411-28. DOI: 10.1146/annurev.me.35.020184.002211. View

Henrich W . Nephrotoxicity of nonsteroidal anti-inflammatory agents. Am J Kidney Dis. 1983; 2(4):478-84. DOI: 10.1016/s0272-6386(83)80083-3. View

Dunn M, Zambraski E . Renal effects of drugs that inhibit prostaglandin synthesis. Kidney Int. 1980; 18(5):609-22. DOI: 10.1038/ki.1980.179. View

10.

Boers M, Croonen A, Dijkmans B, Breedveld F, Eulderink F, Cats A . Renal findings in rheumatoid arthritis: clinical aspects of 132 necropsies. Ann Rheum Dis. 1987; 46(9):658-63. PMC: 1002227. DOI: 10.1136/ard.46.9.658. View

11.

Feldman D, Loose D, Tan S . Nonsteroidal anti-inflammatory drugs cause sodium and water retention in the rat. Am J Physiol. 1978; 234(6):F490-6. DOI: 10.1152/ajprenal.1978.234.6.F490. View

12.

Silverberg D, KIDD E, Shnitka T, Ulan R . Gold nephropathy. A clinical and pathologic study. Arthritis Rheum. 1970; 13(6):812-25. DOI: 10.1002/art.1780130611. View

13.

Brezin J, KATZ S, Schwartz A, Chinitz J . Reversible renal failure and nephrotic syndrome associated with nonsteroidal anti-inflammatory drugs. N Engl J Med. 1979; 301(23):1271-3. DOI: 10.1056/NEJM197912063012306. View

14.

Maddox D, Bennett C, Deen W, Glassock R, Knutson D, Daugharty T . Determinants of glomerular filtration in experimental glomerulonephritis in the rat. J Clin Invest. 1975; 55(2):305-18. PMC: 301749. DOI: 10.1172/JCI107934. View

15.

STRUNK S, ZIFF M . Ultrastructural studies of the passage of gold thiomalate across the renal glomerular capillary wall. Arthritis Rheum. 1970; 13(1):39-52. DOI: 10.1002/art.1780130105. View

16.

Pugliese F, Ciabattoni G . The role of prostaglandins in the control of renal function: renal effects of nonsteroidal anti-inflammatory drugs. Clin Exp Rheumatol. 1984; 2(4):345-52. View

17.

LATERZA G, Clemenzia G, Russo G, Santini P, Scibinetti F, Gentile V . [Behavior of 4 urinary enzymes in healthy subjects in relation to age, sex, body weight and height]. Minerva Med. 1984; 75(47-48):2829-31. View

18.

Blackshear J, Napier J, Davidman M, Stillman M . Renal complications of nonsteroidal antiinflammatory drugs: identification and monitoring of those at risk. Semin Arthritis Rheum. 1985; 14(3):163-75. DOI: 10.1016/0049-0172(85)90035-6. View

19.

Skrifvars B, Tornroth T, Tallqvist G . Gold-induced immune complex nephritis in seronegative rheumatoid arthritis. Ann Rheum Dis. 1977; 36(6):549-56. PMC: 1000161. DOI: 10.1136/ard.36.6.549. View

20.

SALOMON M, Gallo G, POON T, Goldblat M, TCHERTKOFF V . The kidney in rheumatoid arthritis. A study based on renal biopsies. Nephron. 1974; 12(4):297-310. DOI: 10.1159/000180342. View