Memory-related Process in Physiological Status and Alzheimer's Disease

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2020 Apr 13

PMID 32279208

Citations 7

Authors

Seyedeh Nahid Fotuhi

Mohammad Khalaj-Kondori

Mohammad Ali Hoseinpour Feizi

Mahnaz Talebi

Affiliations

Soon will be listed here.

Abstract

Rejecting central dogma around static status of adult mammalian brain, CNS has the nascent neurons generated in subgranular zone of dentate gyrus in hippocampus which develop to novel glutamatergic granule cells, with the innate feature of transmuting to memory disks. Structural plasticity proceeds with synaptic plasticity to process all the developing stages required to successful maturation and functional integration, whereby the memory context is ready to leave the hippocampus toward cortex network through consolidation process, for being installed and run the memory disk forever. However, in Alzheimer's disease, brain deal with subtle deadly progressive loss of synapsis, neuronal dysfunction and ultimately network failure, resulting in memory decay and cognitive decline-concluding that AD destroys memory formation related-pathways.

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