Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2020 Apr 12

PMID 32277935

Citations 22

Authors

Martina Rossi

Myriam Gorospe

Affiliations

Soon will be listed here.

Abstract

Aging is a universal and time-dependent biological decline associated with progressive deterioration of cells, tissues, and organs. Age-related decay can eventually lead to pathology such as cardiovascular and neurodegenerative diseases, cancer, and diabetes. A prominent molecular process underlying aging is the progressive shortening of telomeres, the structures that protect the ends of chromosomes, eventually triggering cellular senescence. Noncoding (nc)RNAs are emerging as major regulators of telomere length homeostasis. In this review, we describe the impact of ncRNAs on telomere function and discuss their implications in senescence and age-related diseases. We discuss emerging therapeutic strategies targeting telomere-regulatory ncRNAs in aging pathology.

Citing Articles

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