RIPK1 Polymorphisms Alter the Susceptibility to Cervical Cancer Among the Uyghur Population in China

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2020 Apr 11

PMID 32272907

Citations 6

Authors

Zulipiyamu Tuoheti

Lili Han

Sulaiya Husaiyin

Xiaoxi Liu

Chunhua Ma

Mayinuer Niyazi

Affiliations

Soon will be listed here.

Abstract

Background: RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK1 polymorphisms and cervical cancer risk among the Uyghur population.

Methods: We performed a case-control study including 342 cervical cancer patients and 498 age-matched healthy controls. Four RIPK1 genetic variants (rs6907943, rs2077681, rs9503400 and rs17548629) were genotyped with Agena MassARRAY platform. The associations between RIPK1 polymorphisms and cervical cancer risk were assessed under Binary logistic regression models. False discovery rate (FDR) was used to improve the results reliability.

Results: The results showed rs2077681 was significantly associated with cervical cancer risk under various genetic models (codominant: OR = 3.14, 95% CI = 1.40-7.07, p = 0.006, FDR-p = 0.018; recessive: OR = 3.20, 95% CI = 1.43-7.16, p = 0.005, FDR-0.018). The stratified analysis indicated that the relationships of rs6907946, rs9503400 and rs17548629 with cervical cancer risk were statistically significant in the subgroup of clinical stage (p < 0.05).

Conclusion: Our findings demonstrated that RIPK1 polymorphisms were associated with cervical cancer susceptibility among the Uyghur population in China, and RIPK1 polymorphisms might be involved in the development of cervical cancer.

Citing Articles

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Clinicopathological and prognosis significance of RIPK1 in patients with cervical squamous cell carcinoma: a retrospective cohort study.

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Rucker A, Chan F Trends Biochem Sci. 2022; 47(4):342-351.

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