Papillomaviruses Go Retro

Overview

Journal Pathogens

Date 2020 Apr 11

PMID 32272661

Citations 9

Authors

Jian Xie

Pengwei Zhang

Mac Crite

Daniel DiMaio

Affiliations

Soon will be listed here.

Abstract

Human papillomaviruses are important pathogens responsible for approximately 5% of cancer as well as other important human diseases, but many aspects of the papillomavirus life cycle are poorly understood. To undergo genome replication, HPV DNA must traffic from the cell surface to the nucleus. Recent findings have revolutionized our understanding of HPV entry, showing that it requires numerous cellular proteins and proceeds via a series of intracellular membrane-bound vesicles that comprise the retrograde transport pathway. This paper reviews the evidence supporting this unique entry mechanism with a focus on the crucial step by which the incoming virus particle is transferred from the endosome into the retrograde pathway. This new understanding provides novel insights into basic cellular biology and suggests novel rational approaches to inhibit HPV infection.

Citing Articles

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