Alpha 2.0
Login Register
» Articles » PMID: 322700

Treatment of TRIC Infection of the Eye with Rifampicin or Chloramphenicol

Overview
Journal Br J Ophthalmol
Specialty Ophthalmology
Date 1977 Apr 1
PMID 322700
Citations 11
Authors
S Darougar
M Viswalingam
J D TREHARNE
J R Kinnison
B R Jones
Affiliations
Soon will be listed here.
Abstract

An open trial was carried out on 63 patients in London to assess the efficacy of 1% rifampicin eye ointment in comparison with 1% chloramphenicol eye ointment in the treatment of sexually transmitted TRIC infection of the eye. Patients included were selected on the basis of positive cultures for Chlamydia trachomatis. Three weeks' treatment with rifampicin eye ointment used 3 times daily was not sufficient to cure the disease, but a 6 or 7 week course gave 90% clinical and microbiological cure rate. Treatment with chloramphenicol eye ointment 3 times daily for 4 to 6 weeks failed to cure the disease.

Citing Articles

Interventions for preventing ophthalmia neonatorum.

Kapoor V, Evans J, Vedula S Cochrane Database Syst Rev. 2020; 9():CD001862.

PMID: 32959365 PMC: 8524318. DOI: 10.1002/14651858.CD001862.pub4.

A double-blind comparison of topical therapy of chlamydial ocular infection (TRIC infection) with rifampicin or chlortetracycline.

Darougar S, Viswalingam N, Hunter P, Yearsley P Br J Ophthalmol. 1981; 65(8):549-52.

PMID: 7028084 PMC: 1039580. DOI: 10.1136/bjo.65.8.549.

Topical therapy of hyperendemic trachoma with rifampicin, oxytetracycline, or spiramycin eye ointments.

Darougar S, Jones B, Viswalingam N, Allami J, Minassian D, Farahmandian M Br J Ophthalmol. 1980; 64(1):37-42.

PMID: 6986898 PMC: 1039345. DOI: 10.1136/bjo.64.1.37.

Clinical and epidemiological features of adenovirus keratoconjunctivitis in London.

Darougar S, Grey R, Thaker U, McSwiggan D Br J Ophthalmol. 1983; 67(1):1-7.

PMID: 6293533 PMC: 1039936. DOI: 10.1136/bjo.67.1.1.

Epidemiological and clinical features of primary herpes simplex virus ocular infection.

Darougar S, Wishart M, Viswalingam N Br J Ophthalmol. 1985; 69(1):2-6.

PMID: 3965025 PMC: 1040512. DOI: 10.1136/bjo.69.1.2.

References
1.
Becker Y . Rifampicin, an antitrachoma antibiotic. Isr J Med Sci. 1972; 8(8):1110-3. View
2.
Darougar S, Jones B . Conjunctival swabbing for the isolation of TRIC agent (Chlamydia). Br J Ophthalmol. 1971; 55(9):585-90. PMC: 1208495. DOI: 10.1136/bjo.55.9.585. View
3.
DAWSON C, HOSHIWARA I, DAGHFOUS T, Messadi M, Vastine D, Schachter J . Topical tetracycline and rifampicin therapy of endemic trachoma in Tunisia. Am J Ophthalmol. 1975; 79(5):803-11. DOI: 10.1016/0002-9394(75)90740-0. View
4.
DAWSON C, Jones B, Darougar S . Blinding and non-blinding trachoma: assessment of intensity of upper tarsal inflammatory disease and disabling lesions. Bull World Health Organ. 1975; 52(3):279-82. PMC: 2366381. View
5.
Becker Y, ASHER Y, Himmel N, Zakay-Rones Z . Anti-trachoma activity of rifampicin and rifamycin SV derivatives. Nature. 1970; 225(5231):454-5. DOI: 10.1038/225454a0. View