Childhood Misfortune and Late-Life Stroke Incidence, 2004-2014

Overview

Journal Gerontologist

Publisher Oxford University Press

Specialty Geriatrics

Date 2020 Apr 9

PMID 32267501

Citations 1

Authors

Callie J Zaborenko

Kenneth F Ferraro

Monica M Williams-Farrelly

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Although most strokes occur in later life, recent studies reveal that negative exposures decades earlier are associated with stroke risk. The purpose of this study was to examine whether accumulated and/or specific domains of early misfortune are related to stroke incidence in later life.

Research Design And Methods: A decade of longitudinal data from stroke-free participants 50 years or older in the Health and Retirement Study were analyzed (N = 12,473). Incident stroke was defined as either self-reported first incident stroke or death due to stroke between 2004 and 2014.

Results: Analyses revealed that accumulated misfortune was associated with increased stroke risk, but the relationship was moderated by wealth. Examining specific domains of childhood misfortune revealed that stroke incidence was greater for persons with behavioral/psychological risks, but that this relationship also was moderated by higher wealth for those with only one behavioral/psychological risk.

Discussion And Implications: Accumulated childhood misfortune and adolescent depression heighten the risk of stroke in later life, but the influence is remediable through adult wealth. Reducing poverty in later life may decrease stroke incidence for persons exposed to negative childhood exposures.

Citing Articles

Early Origins of Frailty: Do Later-Life Social Relationships Alter Trajectories of Decline?.

Williams-Farrelly M, Ferraro K J Aging Health. 2023; 36(5-6):275-285.

PMID: 37358912 PMC: 10749989. DOI: 10.1177/08982643231185426.

References

Morton P, Mustillo S, Ferraro K . Does childhood misfortune raise the risk of acute myocardial infarction in adulthood?. Soc Sci Med. 2014; 104:133-41. PMC: 4010612. DOI: 10.1016/j.socscimed.2013.11.026. View

Mozaffarian D, Benjamin E, Go A, Arnett D, Blaha M, Cushman M . Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. 2015; 133(4):e38-360. DOI: 10.1161/CIR.0000000000000350. View

Ferraro K, Schafer M, Wilkinson L . Childhood Disadvantage and Health Problems in Middle and Later Life: Early Imprints on Physical Health?. Am Sociol Rev. 2016; 81(1):107-133. PMC: 4950981. DOI: 10.1177/0003122415619617. View

Greenfield E, Marks N . Violence from parents in childhood and obesity in adulthood: using food in response to stress as a mediator of risk. Soc Sci Med. 2009; 68(5):791-8. PMC: 2649023. DOI: 10.1016/j.socscimed.2008.12.004. View

Liu L, Xue F, Ma J, Ma M, Long Y, Newschaffer C . Social position and chronic conditions across the life span and risk of stroke: a life course epidemiological analysis of 22,847 American adults in ages over 50. Int J Stroke. 2012; 8 Suppl A100:50-5. PMC: 3610802. DOI: 10.1111/j.1747-4949.2012.00927.x. View

Rogers R, Lawrence E, Montez J . Alcohol's Collateral Damage: Childhood Exposure to Problem Drinkers and Subsequent Adult Mortality Risk. Soc Forces. 2017; 95(2):809-836. PMC: 5381656. DOI: 10.1093/sf/sow074. View

Felitti V, Anda R, Nordenberg D, Williamson D, Spitz A, Edwards V . Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. Am J Prev Med. 1998; 14(4):245-58. DOI: 10.1016/s0749-3797(98)00017-8. View

Glymour M, Avendano M, Haas S, Berkman L . Lifecourse social conditions and racial disparities in incidence of first stroke. Ann Epidemiol. 2008; 18(12):904-12. PMC: 2796851. DOI: 10.1016/j.annepidem.2008.09.010. View

Bonanno G, Mancini A . The human capacity to thrive in the face of potential trauma. Pediatrics. 2008; 121(2):369-75. DOI: 10.1542/peds.2007-1648. View

10.

Avendano M, Glymour M . Stroke disparities in older Americans: is wealth a more powerful indicator of risk than income and education?. Stroke. 2008; 39(5):1533-40. PMC: 3079499. DOI: 10.1161/STROKEAHA.107.490383. View

11.

Glymour M, Maselko J, Gilman S, Patton K, Avendano M . Depressive symptoms predict incident stroke independently of memory impairments. Neurology. 2010; 75(23):2063-70. PMC: 2995534. DOI: 10.1212/WNL.0b013e318200d70e. View

12.

Wilson R, Boyle P, Levine S, Yu L, Anagnos S, Buchman A . Emotional neglect in childhood and cerebral infarction in older age. Neurology. 2012; 79(15):1534-9. PMC: 3475630. DOI: 10.1212/WNL.0b013e31826e25bd. View

13.

Lanz J, Brophy J, Therrien J, Kaouache M, Guo L, Marelli A . Stroke in Adults With Congenital Heart Disease: Incidence, Cumulative Risk, and Predictors. Circulation. 2015; 132(25):2385-94. DOI: 10.1161/CIRCULATIONAHA.115.011241. View

14.

Ferraro K, Morton P . What Do We Mean by Accumulation? Advancing Conceptual Precision for a Core Idea in Gerontology. J Gerontol B Psychol Sci Soc Sci. 2016; 73(2):269-278. PMC: 5927088. DOI: 10.1093/geronb/gbv094. View

15.

Willey J, Moon Y, Paik M, Boden-Albala B, Sacco R, Elkind M . Physical activity and risk of ischemic stroke in the Northern Manhattan Study. Neurology. 2009; 73(21):1774-9. PMC: 2788811. DOI: 10.1212/WNL.0b013e3181c34b58. View

16.

Kelly-Hayes M . Influence of age and health behaviors on stroke risk: lessons from longitudinal studies. J Am Geriatr Soc. 2010; 58 Suppl 2:S325-8. PMC: 3006180. DOI: 10.1111/j.1532-5415.2010.02915.x. View

17.

Clayborne Z, Varin M, Colman I . Systematic Review and Meta-Analysis: Adolescent Depression and Long-Term Psychosocial Outcomes. J Am Acad Child Adolesc Psychiatry. 2018; 58(1):72-79. DOI: 10.1016/j.jaac.2018.07.896. View

18.

Williams M, Kemp B, Ferraro K, Mustillo S . Avoiding the Major Causes of Death: Does Childhood Misfortune Reduce the Likelihood of Being Disease Free in Later Life?. J Gerontol B Psychol Sci Soc Sci. 2018; 74(1):170-180. PMC: 6294238. DOI: 10.1093/geronb/gby039. View

19.

Hill K, Hawkins J, Catalano R, Abbott R, Guo J . Family influences on the risk of daily smoking initiation. J Adolesc Health. 2005; 37(3):202-10. DOI: 10.1016/j.jadohealth.2004.08.014. View

20.

Gliksman M, Kawachi I, Hunter D, Colditz G, Manson J, Stampfer M . Childhood socioeconomic status and risk of cardiovascular disease in middle aged US women: a prospective study. J Epidemiol Community Health. 1995; 49(1):10-5. PMC: 1060067. DOI: 10.1136/jech.49.1.10. View