Hydroethanolic Stem Bark Extract of Attenuates Vincristine-Induced Peripheral Neuropathy in Rats

Overview

Journal Adv Pharmacol Pharm Sci

Publisher Wiley

Date 2020 Apr 8

PMID 32259104

Citations 2

Authors

Yakubu Jibira

Eric Boakye-Gyasi

Wonder Kofi Mensah Abotsi

Isaac Kingsley Amponsah

Donatus Wewura Adongo

Eric Woode

Affiliations

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Abstract

Objective: This study seeks to investigate the possible antiallodynic and antihyperalgesic effects of the hydroethanolic stem bark extract of in a vincristine-induced peripheral neuropathy model in rats. . 0.1 mg kg vincristine was administered intraperitoneally for 5 days followed by 2 days break and continued for another 5 days to establish peripheral neuropathy in Sprague Dawley rats. Effects of (Hook) (family: Leguminosae) is used in the Ghanaian traditional medicine for the management of various pain-related diseases. ) and pregabalin (10-100 mg kg, ) were assessed on tactile, intermediate, mechanical, cold, and hot allodynia as well as in the Randall-Sellito test. Moreover, the levels of total proteins, malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in sciatic nerve tissue homogenates were assayed.

Results: BAE (50-1000 mg kg .) showed significant antiallodynic and antihyperalgesic effects similar to pregabalin by increasing paw withdrawal latency and paw withdrawal threshold in all the behavioral tests used. Also, the extract decreased the levels of MDA (a lipid peroxidation product) as well as MPO and caused a significant increase in endogenous antioxidants (GSH) and antioxidant enzymes (SOD and CAT) in tissue homogenates of treated rats.

Conclusions: Results from this study indicate that the hydroethanolic stem bark extract of exhibits antiallodynic and antihyperalgesic effects in vincristine-induced peripheral neuropathy in rats. in a vincristine-induced peripheral neuropathy model in rats.

Citing Articles

Through Its Powerful Antioxidative Properties, L-Theanine Ameliorates Vincristine-Induced Neuropathy in Rats.

Yang C, Wang M, Soung H, Tseng H, Lin F, Chang K Antioxidants (Basel). 2023; 12(4).

PMID: 37107178 PMC: 10135327. DOI: 10.3390/antiox12040803.

Antinociceptive effects of a hydroethanolic stem bark extract of .

Jibira Y, Boakye-Gyasi E, Abotsi W, Amponsah I, Duah P, Baah F Heliyon. 2022; 8(2):e08917.

PMID: 35198779 PMC: 8851081. DOI: 10.1016/j.heliyon.2022.e08917.

References

McCord J, Fridovich I . Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem. 1969; 244(22):6049-55. View

Salat K, Gawlik K, Witalis J, Pawlica-Gosiewska D, Filipek B, Solnica B . Evaluation of antinociceptive and antioxidant properties of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one in mice. Naunyn Schmiedebergs Arch Pharmacol. 2013; 386(6):493-505. PMC: 3651825. DOI: 10.1007/s00210-013-0847-2. View

Di Cesare Mannelli L, Zanardelli M, Failli P, Ghelardini C . Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin. J Pain. 2012; 13(3):276-84. DOI: 10.1016/j.jpain.2011.11.009. View

McCormick B, Lowes D, Colvin L, Torsney C, Galley H . MitoVitE, a mitochondria-targeted antioxidant, limits paclitaxel-induced oxidative stress and mitochondrial damage in vitro, and paclitaxel-induced mechanical hypersensitivity in a rat pain model. Br J Anaesth. 2016; 117(5):659-666. DOI: 10.1093/bja/aew309. View

Kajander K, Wakisaka S, Bennett G . Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat. Neurosci Lett. 1992; 138(2):225-8. DOI: 10.1016/0304-3940(92)90920-3. View

Kassem L, Gamal El-Din M, Yassin N . Mechanisms of vincristine-induced neurotoxicity: Possible reversal by erythropoietin. Drug Discov Ther. 2012; 5(3):136-43. DOI: 10.5582/ddt.2011.v5.3.136. View

Ohkawa H, Ohishi N, Yagi K . Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95(2):351-8. DOI: 10.1016/0003-2697(79)90738-3. View

Flatters S, Bennett G . Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain. 2004; 109(1-2):150-61. DOI: 10.1016/j.pain.2004.01.029. View

Sertel S, Fu Y, Zu Y, Rebacz B, Konkimalla B, Plinkert P . Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine. Biochem Pharmacol. 2011; 81(6):723-35. DOI: 10.1016/j.bcp.2010.12.026. View

10.

Khalil Z, Liu T, Helme R . Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury. Pain. 1999; 79(1):31-37. DOI: 10.1016/S0304-3959(98)00143-2. View

11.

Back S, Won S, Hong S, Na H . Gabapentin relieves mechanical, warm and cold allodynia in a rat model of peripheral neuropathy. Neurosci Lett. 2004; 368(3):341-4. DOI: 10.1016/j.neulet.2004.07.091. View

12.

Chong M, Bajwa Z . Diagnosis and treatment of neuropathic pain. J Pain Symptom Manage. 2003; 25(5 Suppl):S4-S11. DOI: 10.1016/s0885-3924(03)00064-2. View

13.

Chiba T, Oka Y, Sashida H, Kanbe T, Abe K, Utsunomiya I . Vincristine-induced peripheral neuropathic pain and expression of transient receptor potential vanilloid 1 in rat. J Pharmacol Sci. 2017; 133(4):254-260. DOI: 10.1016/j.jphs.2017.03.004. View

14.

Jain V, Jaggi A, Singh N . Ameliorative potential of rosiglitazone in tibial and sural nerve transection-induced painful neuropathy in rats. Pharmacol Res. 2009; 59(6):385-92. DOI: 10.1016/j.phrs.2009.02.001. View

15.

Gore M, Brandenburg N, Dukes E, Hoffman D, Tai K, Stacey B . Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep. J Pain Symptom Manage. 2005; 30(4):374-85. DOI: 10.1016/j.jpainsymman.2005.04.009. View

16.

Thomadaki H, Floros K, Scorilas A . Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12. Ann N Y Acad Sci. 2009; 1171:276-83. DOI: 10.1111/j.1749-6632.2009.04912.x. View

17.

Klangprapan S, Chaiyarit P, Hormdee D, Kampichai A, Khampitak T, Daduang J . Salivary Myeloperoxidase, Assessed by 3,3'-Diaminobenzidine Colorimetry, Can Differentiate Periodontal Patients from Nonperiodontal Subjects. Enzyme Res. 2016; 2016:7517928. PMC: 4871957. DOI: 10.1155/2016/7517928. View

18.

Mizoguchi H, Watanabe C, Yonezawa A, Sakurada S . New therapy for neuropathic pain. Int Rev Neurobiol. 2009; 85:249-60. DOI: 10.1016/S0074-7742(09)85019-8. View

19.

Ameyaw E, Woode E, Boakye-Gyasi E, Abotsi W, Kyekyeku J, Adosraku R . Anti-allodynic and Anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain. Pharmacognosy Res. 2014; 6(2):172-9. PMC: 3996755. DOI: 10.4103/0974-8490.129041. View

20.

Areti A, Yerra V, Naidu V, Kumar A . Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy. Redox Biol. 2014; 2:289-95. PMC: 3909836. DOI: 10.1016/j.redox.2014.01.006. View