Food Additives and Microbiota

Overview

Journal North Clin Istanb

Publisher Kare Publishing

Specialty General Medicine

Date 2020 Apr 8

PMID 32259044

Citations 14

Authors

Fatih Gultekin

Manolya Eser Oner

Hasan Basri Savas

Bora Dogan

Affiliations

Soon will be listed here.

Abstract

The use of food additives in food production is inevitable in this modern world. Although only a safe amount of food additives is approved, their safety has always been questioned. To our knowledge, the effects of food additives on microbiota have not been investigated in a detailed manner in the literature so far. In this review, the effects of artificial sweeteners, sugar alcohols, emulsifiers, food colorants, flavor enhancers, thickeners, anticaking agents, and preservatives on microbiota were reviewed. Even though most of the results illustrated negative outcomes, few of them showed positive effects of food additives on the microbiota. Although it is difficult to obtain exact results due to differences in experimental animals and models, said the findings suggest that nonnutritive synthetic sweeteners may lead to glucose intolerance by affecting microbiota and a part of sugar alcohols show similar effects like probiotics.

Citing Articles

Carrageenan in the Diet: Friend or Foe for Inflammatory Bowel Disease?.

Kimilu N, Gladys-Cieszynska K, Pieszko M, Mankowska-Wierzbicka D, Folwarski M Nutrients. 2024; 16(11).

PMID: 38892712 PMC: 11174395. DOI: 10.3390/nu16111780.

Carrageenan as a Potential Factor of Inflammatory Bowel Diseases.

Komisarska P, Pinyosinwat A, Saleem M, Szczuko M Nutrients. 2024; 16(9).

PMID: 38732613 PMC: 11085445. DOI: 10.3390/nu16091367.

Determination of antioxidant capacity, citric acid, phenolic compounds, physicochemical and sensory properties of Pepino marmalade yogurts enriched with erythritol and amaranth flour at different concentrations.

Yangilar F Food Sci Biotechnol. 2023; 32(4):531-542.

PMID: 36911321 PMC: 9992480. DOI: 10.1007/s10068-022-01215-8.

Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn's disease. The ENIGMA study.

Loayza J, Kang S, Schooth L, Teh J, de Klerk A, Noon E Gut Microbes. 2023; 15(1):2172670.

PMID: 36852457 PMC: 9980662. DOI: 10.1080/19490976.2023.2172670.

The Impact of Food Additives on the Abundance and Composition of Gut Microbiota.

Zhou X, Qiao K, Wu H, Zhang Y Molecules. 2023; 28(2).

PMID: 36677689 PMC: 9864936. DOI: 10.3390/molecules28020631.

References

Bian X, Tu P, Chi L, Gao B, Ru H, Lu K . Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions. Food Chem Toxicol. 2017; 107(Pt B):530-539. PMC: 5647777. DOI: 10.1016/j.fct.2017.04.045. View

Hengst C, Ptok S, Roessler A, Fechner A, Jahreis G . Effects of polydextrose supplementation on different faecal parameters in healthy volunteers. Int J Food Sci Nutr. 2008; 60 Suppl 5:96-105. DOI: 10.1080/09637480802526760. View

Prasai T, Walsh K, Bhattarai S, Midmore D, Van T, Moore R . Biochar, Bentonite and Zeolite Supplemented Feeding of Layer Chickens Alters Intestinal Microbiota and Reduces Campylobacter Load. PLoS One. 2016; 11(4):e0154061. PMC: 4845986. DOI: 10.1371/journal.pone.0154061. View

Zhukova L, Kiwi J, Nikandrov V . TiO2 nanoparticles suppress Escherichia coli cell division in the absence of UV irradiation in acidic conditions. Colloids Surf B Biointerfaces. 2012; 97:240-7. DOI: 10.1016/j.colsurfb.2012.03.010. View

Jin Y, Wu S, Zeng Z, Fu Z . Effects of environmental pollutants on gut microbiota. Environ Pollut. 2017; 222:1-9. DOI: 10.1016/j.envpol.2016.11.045. View

Grotz V, Pi-Sunyer X, Porte Jr D, Roberts A, Richard Trout J . A 12-week randomized clinical trial investigating the potential for sucralose to affect glucose homeostasis. Regul Toxicol Pharmacol. 2017; 88:22-33. DOI: 10.1016/j.yrtph.2017.05.011. View

Goto Y, Anzai M, Chiba M, OHNEDA A, Kawashima S . Clinical effects of xylitol on carbohydrate and lipid metabolism in diabetes. Lancet. 1965; 2(7419):918-21. DOI: 10.1016/s0140-6736(65)92900-4. View

Dimitrijevic D, Shaw A, Florence A . Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells. J Pharm Pharmacol. 2000; 52(2):157-62. DOI: 10.1211/0022357001773805. View

Palmnas M, Cowan T, Bomhof M, Su J, Reimer R, Vogel H . Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat. PLoS One. 2014; 9(10):e109841. PMC: 4197030. DOI: 10.1371/journal.pone.0109841. View

10.

Yebra M . Cross-talk between the L-sorbose and D-sorbitol (D-glucitol) metabolic pathways in Lactobacillus casei. Microbiology (Reading). 2002; 148(Pt 8):2351-2359. DOI: 10.1099/00221287-148-8-2351. View

11.

LEDERBERG J . Infectious history. Science. 2000; 288(5464):287-93. DOI: 10.1126/science.288.5464.287. View

12.

Oku T, Akiba M, Lee M, Moon S, Hosoya N . Metabolic fate of ingested [14C]-maltitol in man. J Nutr Sci Vitaminol (Tokyo). 1991; 37(5):529-44. DOI: 10.3177/jnsv.37.529. View

13.

Ishikawa M, Miyashita M, Kawashima Y, Nakamura T, Saitou N, Modderman J . Effects of oral administration of erythritol on patients with diabetes. Regul Toxicol Pharmacol. 1996; 24(2 Pt 2):S303-8. DOI: 10.1006/rtph.1996.0112. View

14.

Li M, Li G, Shang Q, Chen X, Liu W, Pi X . In vitro fermentation of alginate and its derivatives by human gut microbiota. Anaerobe. 2016; 39:19-25. DOI: 10.1016/j.anaerobe.2016.02.003. View

15.

Jie Z, Craig S . Studies on the effects of polydextrose intake on physiologic functions in Chinese people. Am J Clin Nutr. 2000; 72(6):1503-9. DOI: 10.1093/ajcn/72.6.1503. View

16.

Yousaf M, Goodarzi Boroojeni F, Vahjen W, Manner K, Hafeez A, Ur-Rehman H . Encapsulated benzoic acid supplementation in broiler diets influences gut bacterial composition and activity. Br Poult Sci. 2016; 58(2):122-131. DOI: 10.1080/00071668.2016.1262000. View

17.

Salminen S, Salminen E, Koivistoinen P, Bridges J, Marks V . Gut microflora interactions with xylitol in the mouse, rat and man. Food Chem Toxicol. 1985; 23(11):985-90. DOI: 10.1016/0278-6915(85)90248-0. View

18.

Pepino M . Metabolic effects of non-nutritive sweeteners. Physiol Behav. 2015; 152(Pt B):450-5. PMC: 4661066. DOI: 10.1016/j.physbeh.2015.06.024. View

19.

Abou-Donia M, El-Masry E, Abdel-Rahman A, McLendon R, Schiffman S . Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. J Toxicol Environ Health A. 2008; 71(21):1415-29. DOI: 10.1080/15287390802328630. View

20.

Liu P, Duan W, Wang Q, Li X . The damage of outer membrane of Escherichia coli in the presence of TiO2 combined with UV light. Colloids Surf B Biointerfaces. 2010; 78(2):171-6. DOI: 10.1016/j.colsurfb.2010.02.024. View