The Role of Bone-Derived Exosomes in Regulating Skeletal Metabolism and Extraosseous Diseases

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2020 Apr 8

PMID 32258024

Citations 23

Authors

Huili Lyu

Ye Xiao

Qi Guo

Yan Huang

Xianghang Luo

Affiliations

Soon will be listed here.

Abstract

Bone-derived exosomes are naturally existing nano-sized extracellular vesicles secreted by various cells, such as bone marrow stromal cells, osteoclasts, osteoblasts, and osteocytes, containing multifarious proteins, lipids, and nucleic acids. Accumulating evidence indicates that bone-derived exosomes are involved in the regulation of skeletal metabolism and extraosseous diseases through modulating intercellular communication and the transfer of materials. Following the development of research, we found that exosomes can be considered as a potential candidate as a drug delivery carrier thanks to its ability to transport molecules into targeted cells with high stability, safety, and efficiency. This review aims to discuss the emerging role of bone-derived exosomes in skeletal metabolism and extraosseous diseases as well as their potential role as candidate biomarkers or for developing new therapeutic strategies.

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