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Double Negative T Cells, a Potential Biomarker for Systemic Lupus Erythematosus

Overview
Journal Precis Clin Med
Publisher Oxford University Press
Specialty General Medicine
Date 2020 Apr 8
PMID 32257532
Citations 22
Authors
Jessy J Alexander
Alexander Jacob
Anthony Chang
Richard J Quigg
James N Jarvis
Affiliations
Soon will be listed here.
Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that is a challenge to diagnose and treat. There is an urgent need for biomarkers to help define organ involvement, and more effective therapies. A unique population of T cells, the CD3CD4CD8 (DNeg) cells, is significantly increased in lupus patients. Twenty-seven cases (53%) of pediatric SLE patients had elevated DNeg cells in their peripheral blood, which correlated with kidney function (  = 0.54). Significant infiltration of DNeg cells was observed in both adult and pediatric lupus kidneys by immunofluorescence. For the first time, this study provides direct evidence that DNeg cells facilitate kidney injury in preclinical 8-week-old MRL/ lupus mice. In lupus mice, the increase in DNeg cells tracked with worsening disease and correlated with kidney function (  = 0.85). Our results show that DNeg cells can cause kidney dysfunction, increase in number with increase in disease pathology, and could serve as a potential biomarker.

Citing Articles

Nonspecific increase of αβTCR double-negative T cells in pediatric rheumatic diseases.

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Double-negative T cells in pediatric rheumatic diseases.

Poddighe D, Maulenkul T, Dossybayeva K, Zhubanova G, Mukusheva Z, Akhmaltdinova L Clin Exp Pediatr. 2024; 67(12):632-640.

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Celastrol ameliorates lupus by promoting apoptosis of autoimmune T cells and preventing autoimmune response in MRL/lpr mice.

Xie T, Rui H, Liu H, Liu X, Liu X, Li P Lupus Sci Med. 2024; 11(1).

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Double-Negative T (DNT) Cells in Patients with Systemic Lupus Erythematosus.

Poddighe D, Dossybayeva K, Kozhakhmetov S, Rozenson R, Assylbekova M Biomedicines. 2024; 12(1).

PMID: 38255272 PMC: 10812956. DOI: 10.3390/biomedicines12010166.

Helios as a Potential Biomarker in Systemic Lupus Erythematosus and New Therapies Based on Immunosuppressive Cells.

Paris-Munoz A, Leon-Triana O, Perez-Martinez A, Barber D Int J Mol Sci. 2024; 25(1).

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References
1.
Quandt D, Rothe K, Scholz R, Baerwald C, Wagner U . Peripheral CD4CD8 double positive T cells with a distinct helper cytokine profile are increased in rheumatoid arthritis. PLoS One. 2014; 9(3):e93293. PMC: 3965555. DOI: 10.1371/journal.pone.0093293. View
2.
Rumfelt L, Zhou Y, Rowley B, Shinton S, Hardy R . Lineage specification and plasticity in CD19- early B cell precursors. J Exp Med. 2006; 203(3):675-87. PMC: 2118241. DOI: 10.1084/jem.20052444. View
3.
Ohga S, Nomura A, Takahata Y, Ihara K, Takada H, Wakiguchi H . Dominant expression of interleukin 10 but not interferon gamma in CD4(-)CD8(-)alphabetaT cells of autoimmune lymphoproliferative syndrome. Br J Haematol. 2002; 119(2):535-8. DOI: 10.1046/j.1365-2141.2002.03848.x. View
4.
Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z . Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev. 2006; 212:8-27. DOI: 10.1111/j.0105-2896.2006.00427.x. View
5.
Moulton V, Tsokos G . Abnormalities of T cell signaling in systemic lupus erythematosus. Arthritis Res Ther. 2011; 13(2):207. PMC: 3132009. DOI: 10.1186/ar3251. View