Bone Mass Loss and Sarcopenia in Ecuadorian Patients

Overview

Journal J Aging Res

Publisher Wiley

Specialty Geriatrics

Date 2020 Apr 8

PMID 32257440

Citations 5

Authors

M Intriago

G Maldonado

R Guerrero

O D Messina

C Rios

Affiliations

Soon will be listed here.

Abstract

Objective: To study the association between osteoporosis and sarcopenia and determine the prevalence of osteosarcopenia in patients who attended a rheumatology center in Ecuador.

Methods: A cross-sectional study was conducted in a population of patients who had a densitometric study. The diagnosis of sarcopenia was determined by the DXA standard gold test, screening, and conventional methods (bioimpedance, anthropometric measurements, SARC-F, muscle function, and gait test).

Results: A total of 92 patients were studied. The median age was 66 ± 10, 90% females. Using the criteria of SMI, 65% had sarcopenia of which 9% had only sarcopenia and 56% had osteosarcopenia; 22% had only osteopenia/osteoporosis; and 13% none of these conditions. The prevalence of sarcopenia according to handgrip strength was 60%, gait speed 45%, and SARC-F score 40%. The prevalence of osteosarcopenia according to handgrip strength was 51%, gait speed 34%, and SARC-F score 32%. Osteoporosis was associated with a higher prevalence of sarcopenia using the criteria of SMI since 40% had sarcopenia in the normal DXA group, 64% in the osteopenia group, and 76% in the osteoporosis group (=0.017). Of the women, 69% had sarcopenia compared to 33% of the men (=0.034). The BMI was lower in the group with sarcopenia (25.1 ± 4.1 kg/m) compared to the group without sarcopenia (29.4 ± 4.1 kg/m, < 0.001). Patients with osteosarcopenia and sarcopenia had lower BMI, handgrip strength, ASM, SMI, and total-body skeletal muscle mass than those with osteopenia/osteoporosis or normal patients.

Conclusion: 65% of the studied population had sarcopenia. It is clear that the prevalence of sarcopenia is higher in patients with greater loss of bone mass. Identifying pathways that affect both bone and muscle could facilitate the development of treatments that simultaneously improve osteoporosis and sarcopenia.

Citing Articles

Prevalence and risk factors of osteosarcopenia: a systematic review and meta-analysis.

Huang T, Li C, Chen F, Xie D, Yang C, Chen Y BMC Geriatr. 2023; 23(1):369.

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Use of artificial neural networks in the prognosis of musculoskeletal diseases-a scoping review.

Qiu F, Li J, Zhang R, Legerlotz K BMC Musculoskelet Disord. 2023; 24(1):86.

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Chew S, Tey S, Yalawar M, Liu Z, Baggs G, How C BMC Geriatr. 2022; 22(1):997.

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References

Yoo J, Ha Y, Kwon H, Lee Y, Koo K, Yoo M . High Prevalence of Sarcopenia in Korean Patients after Hip Fracture: a Case-Control Study. J Korean Med Sci. 2016; 31(9):1479-84. PMC: 4974192. DOI: 10.3346/jkms.2016.31.9.1479. View

Yang M, Hu X, Xie L, Zhang L, Zhou J, Lin J . Comparing Mini Sarcopenia Risk Assessment With SARC-F for Screening Sarcopenia in Community-Dwelling Older Adults. J Am Med Dir Assoc. 2018; 20(1):53-57. DOI: 10.1016/j.jamda.2018.04.012. View

da Silva A, Matos A, Ribeiro R, Gil A, Valente A, Bicho M . Sarcopenia and osteoporosis in Portuguese centenarians. Eur J Clin Nutr. 2016; 71(1):56-63. DOI: 10.1038/ejcn.2016.174. View

Lera L, Albala C, Sanchez H, Angel B, Hormazabal M, Marquez C . Prevalence of Sarcopenia in Community-Dwelling Chilean Elders According to an Adapted Version of the European Working Group on Sarcopenia in Older People (EWGSOP) Criteria. J Frailty Aging. 2017; 6(1):12-17. DOI: 10.14283/jfa.2016.117. View

Cruz-Jentoft A, Baeyens J, Bauer J, Boirie Y, Cederholm T, Landi F . Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010; 39(4):412-23. PMC: 2886201. DOI: 10.1093/ageing/afq034. View

DI Monaco M, Vallero F, Di Monaco R, Tappero R . Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture. Arch Gerontol Geriatr. 2010; 52(1):71-4. DOI: 10.1016/j.archger.2010.02.002. View

. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2001; 894:i-xii, 1-253. View

Tagliaferri C, Wittrant Y, Davicco M, Walrand S, Coxam V . Muscle and bone, two interconnected tissues. Ageing Res Rev. 2015; 21:55-70. DOI: 10.1016/j.arr.2015.03.002. View

Frost H . Bone's mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol. 2003; 275(2):1081-101. DOI: 10.1002/ar.a.10119. View

10.

Rochefort G, Pallu S, Benhamou C . Osteocyte: the unrecognized side of bone tissue. Osteoporos Int. 2010; 21(9):1457-69. DOI: 10.1007/s00198-010-1194-5. View

11.

Yoo J, Kim H, Ha Y, Kwon H, Koo K . Osteosarcopenia in Patients with Hip Fracture Is Related with High Mortality. J Korean Med Sci. 2018; 33(4):e27. PMC: 5760812. DOI: 10.3346/jkms.2018.33.e27. View

12.

Scott D, Seibel M, Cumming R, Naganathan V, Blyth F, Le Couteur D . Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2018; 74(6):827-834. DOI: 10.1093/gerona/gly162. View

13.

Lang T, Streeper T, Cawthon P, Baldwin K, Taaffe D, Harris T . Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int. 2009; 21(4):543-59. PMC: 2832869. DOI: 10.1007/s00198-009-1059-y. View

14.

Janssen I, Shepard D, Katzmarzyk P, Roubenoff R . The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc. 2003; 52(1):80-5. DOI: 10.1111/j.1532-5415.2004.52014.x. View

15.

Hong W, Cheng Q, Zhu X, Zhu H, Li H, Zhang X . Prevalence of Sarcopenia and Its Relationship with Sites of Fragility Fractures in Elderly Chinese Men and Women. PLoS One. 2015; 10(9):e0138102. PMC: 4569344. DOI: 10.1371/journal.pone.0138102. View

16.

Binkley N, Buehring B . Beyond FRAX: it's time to consider "sarco-osteopenia". J Clin Densitom. 2009; 12(4):413-6. DOI: 10.1016/j.jocd.2009.06.004. View

17.

Tramontano A, Veronese N, Sergi G, Manzato E, Rodriguez-Hurtado D, Maggi S . Prevalence of sarcopenia and associated factors in the healthy older adults of the Peruvian Andes. Arch Gerontol Geriatr. 2016; 68:49-54. DOI: 10.1016/j.archger.2016.09.002. View

18.

Dempster D . Osteoporosis and the burden of osteoporosis-related fractures. Am J Manag Care. 2011; 17 Suppl 6:S164-9. View

19.

Gabat J, Faltado Jr A, Sedurante M, Tee M . Association of obesity and sarcopenia among adult Filipinos. Osteoporos Sarcopenia. 2019; 4(3):109-113. PMC: 6362942. DOI: 10.1016/j.afos.2018.08.001. View

20.

Huo Y, Suriyaarachchi P, Gomez F, Curcio C, Boersma D, Muir S . Phenotype of osteosarcopenia in older individuals with a history of falling. J Am Med Dir Assoc. 2014; 16(4):290-5. DOI: 10.1016/j.jamda.2014.10.018. View