Occurrence of Multidrug-resistant Uropathogens Implicated in Asymptomatic Bacteriuria in Adults with Sickle Cell Disease in Ile-Ife, Southwest Nigeria

Overview

Journal Oman Med J

Specialty General Medicine

Date 2020 Apr 8

PMID 32257418

Citations 3

Authors

Timothy Bebe

Babatunde Odetoyin

Rahman Bolarinwa

Affiliations

Soon will be listed here.

Abstract

Objectives: We sought to determine the prevalence of asymptomatic bacteriuria (ASB) in patients with sickle cell disease (SCD), the susceptibility profile of its agents and their extended-spectrum β-lactamase (ESBL) production.

Methods: Fifty-nine patients with SCD and 116 healthy controls were investigated. Urine samples were collected and cultured by standard techniques. We used the disc diffusion technique to determine antibiotic susceptibility. ESBL was detected by the combination disc method and detection of , , and genes by multiplex-polymerase chain reaction.

Results: The prevalence of ASB was higher among patients with SCD (8.6%) than controls (0.9%) ( 0.016), predominantly among females. Coagulase-negative staphylococci (n = 2; 33.3%) predominated among the isolates. Other uropathogens included , , and . All isolates were sensitive to meropenem but were resistant to ceftazidime, ampicillin, and tetracycline. , , and were detected in .

Conclusions: The prevalence of ASB is high in patients with SCD predominantly among females. Rare multidrug-resistant uropathogens were implicated. We posit a need for resistance surveillance programs and antibiotic stewardship to prevent treatment failure and reduce drug resistance.

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