Antiarrhythmic Mechanisms of Chinese Herbal Medicine Dingji Fumai Decoction

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2020 Apr 8

PMID 32256664

Citations 12

Authors

Bo Liang

Yan Zhou

Ling Fu

Hui-Ling Liao

Affiliations

Soon will be listed here.

Abstract

Background: Dingji Fumai decoction (DFD) is used to treat ventricular arrhythmia, and it has provided a very good curative effect. However, its cellular electrophysiological mechanism is unknown.

Methods: Electrocardiogram was recorded, and oxidative stress response and ion-channel-related molecules were detected in rats with barium chloride- and aconitine-induced ventricular arrhythmia. Moreover, whole-cell patch-clamp assay was used to investigate the inhibitory effect of DFD on Nav in Chinese hamster ovary cells.

Results: DFD prolonged the occurrence time and shortened the duration of ventricular arrhythmia, decreased the malondialdehyde and increased the superoxide dismutase, and alleviated the activation of Na-K-ATPase and connexin-43. DFD suppressed Navdose-dependently with an IC of 24.0 ± 2.4 mg/mL.

Conclusions: The clinical antiarrhythmic mechanisms of DFD are based on its antioxidant potential, alleviation of Na-K-ATPase and connexin-43, and class I antiarrhythmic properties by suppressing Navdose-dependently with an IC of 24.0 ± 2.4 mg/mL.

Citing Articles

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Guanxin V Relieves Ventricular Remodeling by Inhibiting Inflammation: Implication from Virtual Screening, Systematic Pharmacology, Molecular Docking, and Experimental Validation.

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Liang B, Li R, Liang Y, Gu N Front Cardiovasc Med. 2022; 8:778005.

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Zhu Y, Liang B, Gu N Front Cardiovasc Med. 2021; 8:753095.

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