Outcomes of RIP Kinase Signaling During Neuroinvasive Viral Infection

Overview

Journal Curr Top Microbiol Immunol

Specialties Allergy & Immunology
Microbiology

Date 2020 Apr 8

PMID 32253569

Citations 5

Authors

Brian P Daniels

Andrew Oberst

Affiliations

Soon will be listed here.

Abstract

Neuroinvasive viral diseases are a considerable and growing burden on global public health. Despite this, these infections remain poorly understood, and the molecular mechanisms that govern protective versus pathological neuroinflammatory responses to infection are a matter of intense investigation. Recent evidence suggests that necroptosis, an immunogenic form of programmed cell death, may contribute to the pathogenesis of viral encephalitis. However, the receptor-interacting protein (RIP) kinases that coordinate necroptosis, RIPK1 and RIPK3, also appear to have unexpected, cell death-independent functions in the central nervous system (CNS) that promote beneficial neuroinflammation during neuroinvasive infection. Here, we review the emerging evidence in this field, with additional discussion of recent work examining roles for RIPK signaling and necroptosis during noninfectious pathologies of the CNS, as these studies provide important additional insight into the potential for specialized neuroimmune functions for the RIP kinases.

Citing Articles

The kinase RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during central nervous system viral infection.

Estevez I, Buckley B, Lindman M, Panzera N, Chou T, McCourt M Immunity. 2025; 58(3):666-682.e6.

PMID: 39999836 PMC: 11903149. DOI: 10.1016/j.immuni.2025.01.017.

Astrocytic RIPK3 exerts protective anti-inflammatory activity during viral encephalitis via induction of serpin protease inhibitors.

Lindman M, Estevez I, Marmut E, DaPrano E, Chou T, Newman K bioRxiv. 2024; .

PMID: 38826345 PMC: 11142122. DOI: 10.1101/2024.05.21.595181.

RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during CNS viral infection.

Estevez I, Buckley B, Panzera N, Lindman M, Chou T, McCourt M bioRxiv. 2024; .

PMID: 38712188 PMC: 11071512. DOI: 10.1101/2024.04.26.591333.

RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection.

Lindman M, Angel J, Estevez I, Chang N, Chou T, McCourt M PLoS Pathog. 2023; 19(11):e1011813.

PMID: 38011306 PMC: 10703404. DOI: 10.1371/journal.ppat.1011813.

Paradoxical roles for programmed cell death signaling during viral infection of the central nervous system.

Angel J, Daniels B Curr Opin Neurobiol. 2022; 77:102629.

PMID: 36162201 PMC: 10754211. DOI: 10.1016/j.conb.2022.102629.

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