Factors Influencing Epigenetic Mechanisms: Is There A Role for Bariatric Surgery?

Overview

Journal High Throughput

Publisher MDPI

Date 2020 Apr 5

PMID 32244851

Citations 11

Authors

Alessio Metere

Claire E Graves

Affiliations

Soon will be listed here.

Abstract

Epigenetics is the interaction between the genome and environmental stimuli capable of influencing gene expression during development and aging. A large number of studies have shown that metabolic diseases are highly associated with epigenetic alterations, suggesting that epigenetic factors may play a central role in obesity. To investigate these relationships, we focus our attention on the most common epigenetic modifications that occur in obesity, including DNA methylation and post-translational modifications of histones. We also consider bariatric surgery as an epigenetic factor, evaluating how the anatomic and physiologic modifications induced by these surgical techniques can change gene expression. Here we discuss the importance of epigenetic mechanisms in chronic disease and cancer, and the role of epigenetic disturbances in obesity, with a focus on the role of bariatric surgery.

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References

Singh N, Miranda K, Singh U, Nagarkatti P, Nagarkatti M . Diethylstilbestrol (DES) induces autophagy in thymocytes by regulating Beclin-1 expression through epigenetic modulation. Toxicology. 2018; 410:49-58. PMC: 6463288. DOI: 10.1016/j.tox.2018.08.012. View

Coppede F, Seghieri M, Stoccoro A, Santini E, Giannini L, Rossi C . DNA methylation of genes regulating appetite and prediction of weight loss after bariatric surgery in obese individuals. J Endocrinol Invest. 2018; 42(1):37-44. DOI: 10.1007/s40618-018-0881-5. View

Wei Y, Tepperman K, Huang M, Sartor M, Puga A . Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin. J Biol Chem. 2003; 279(6):4110-9. DOI: 10.1074/jbc.M310800200. View

Wahl S, Drong A, Lehne B, Loh M, Scott W, Kunze S . Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature. 2016; 541(7635):81-86. PMC: 5570525. DOI: 10.1038/nature20784. View

Deltour S, Chopin V, Leprince D . [Epigenetics and cancer]. Med Sci (Paris). 2005; 21(4):405-11. DOI: 10.1051/medsci/2005214405. View

Shukla S, Penta D, Mondal P, Meeran S . Epigenetics of Breast Cancer: Clinical Status of Epi-drugs and Phytochemicals. Adv Exp Med Biol. 2019; 1152:293-310. DOI: 10.1007/978-3-030-20301-6_16. View

Sala P, Torrinhas R, Fonseca D, Ravacci G, Waitzberg D, Giannella-Neto D . Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass. Diabetol Metab Syndr. 2017; 9:15. PMC: 5322591. DOI: 10.1186/s13098-017-0214-4. View

Curran K, Bracha S, Wong C, Beaver L, Stevens J, Ho E . Sulforaphane absorption and histone deacetylase activity following single dosing of broccoli sprout supplement in normal dogs. Vet Med Sci. 2018; 4(4):357-363. PMC: 6236138. DOI: 10.1002/vms3.118. View

Antwih D, Gabbara K, Lancaster W, Ruden D, Zielske S . Radiation-induced epigenetic DNA methylation modification of radiation-response pathways. Epigenetics. 2013; 8(8):839-48. PMC: 3883787. DOI: 10.4161/epi.25498. View

10.

Merrill S, Gladish N, Kobor M . Social Environment and Epigenetics. Curr Top Behav Neurosci. 2019; 42:83-126. DOI: 10.1007/7854_2019_114. View

11.

Yengo L, Sidorenko J, Kemper K, Zheng Z, Wood A, Weedon M . Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Hum Mol Genet. 2018; 27(20):3641-3649. PMC: 6488973. DOI: 10.1093/hmg/ddy271. View

12.

Benton M, Johnstone A, Eccles D, Harmon B, Hayes M, Lea R . An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss. Genome Biol. 2015; 16:8. PMC: 4301800. DOI: 10.1186/s13059-014-0569-x. View

13.

Ahrens M, Ammerpohl O, von Schonfels W, Kolarova J, Bens S, Itzel T . DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery. Cell Metab. 2013; 18(2):296-302. DOI: 10.1016/j.cmet.2013.07.004. View

14.

Keller M, Hopp L, Liu X, Wohland T, Rohde K, Cancello R . Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity. Mol Metab. 2017; 6(1):86-100. PMC: 5220399. DOI: 10.1016/j.molmet.2016.11.003. View

15.

Khan H, Singh R, Tiwari R, Gangopadhyay S, Roy S, Singh D . Mercury exposure induces cytoskeleton disruption and loss of renal function through epigenetic modulation of MMP9 expression. Toxicology. 2017; 386:28-39. DOI: 10.1016/j.tox.2017.05.006. View

16.

Sayols-Baixeras S, Subirana I, Fernandez-Sanles A, Senti M, Lluis-Ganella C, Marrugat J . DNA methylation and obesity traits: An epigenome-wide association study. The REGICOR study. Epigenetics. 2017; 12(10):909-916. PMC: 5788444. DOI: 10.1080/15592294.2017.1363951. View

17.

Waddington C . Towards a theoretical biology. Nature. 1968; 218(5141):525-7. DOI: 10.1038/218525a0. View

18.

Khan F, Momtaz S, Abdollahi M . The relationship between mercury exposure and epigenetic alterations regarding human health, risk assessment and diagnostic strategies. J Trace Elem Med Biol. 2019; 52:37-47. DOI: 10.1016/j.jtemb.2018.11.006. View

19.

Donkin I, Versteyhe S, Ingerslev L, Qian K, Mechta M, Nordkap L . Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans. Cell Metab. 2015; 23(2):369-78. DOI: 10.1016/j.cmet.2015.11.004. View

20.

Barres R, Kirchner H, Rasmussen M, Yan J, Kantor F, Krook A . Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 2013; 3(4):1020-7. DOI: 10.1016/j.celrep.2013.03.018. View