Shape Anisotropic Iron Oxide-Based Magnetic Nanoparticles: Synthesis and Biomedical Applications

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Apr 5

PMID 32244817

Citations 51

Authors

Raquel G D Andrade

Sergio R S Veloso

Elisabete M S Castanheira

Affiliations

Soon will be listed here.

Abstract

Research on iron oxide-based magnetic nanoparticles and their clinical use has been, so far, mainly focused on the spherical shape. However, efforts have been made to develop synthetic routes that produce different anisotropic shapes not only in magnetite nanoparticles, but also in other ferrites, as their magnetic behavior and biological activity can be improved by controlling the shape. Ferrite nanoparticles show several properties that arise from finite-size and surface effects, like high magnetization and superparamagnetism, which make them interesting for use in nanomedicine. Herein, we show recent developments on the synthesis of anisotropic ferrite nanoparticles and the importance of shape-dependent properties for biomedical applications, such as magnetic drug delivery, magnetic hyperthermia and magnetic resonance imaging. A brief discussion on toxicity of iron oxide nanoparticles is also included.

Citing Articles

Iron Oxide Nanoparticle-Based T Contrast Agents for Magnetic Resonance Imaging: A Review.

Zhang D, Zhang J, Bian X, Zhang P, Wu W, Zuo X Nanomaterials (Basel). 2025; 15(1.

PMID: 39791792 PMC: 11722098. DOI: 10.3390/nano15010033.

Microfabrication Technologies for Nanoinvasive and High-Resolution Magnetic Neuromodulation.

Ge C, Masalehdan T, Shojaei Baghini M, Duran Toro V, Signorelli L, Thomson H Adv Sci (Weinh). 2024; 11(46):e2404254.

PMID: 39445520 PMC: 11633526. DOI: 10.1002/advs.202404254.

Synthesis, modifications, and applications of iron-based nanoparticles.

Shahbazi R, Behbahani F Mol Divers. 2024; 28(6):4515-4552.

PMID: 38740610 DOI: 10.1007/s11030-023-10801-9.

Biocompatible gelatin-coated ferrite nanoparticles: A magnetic approach to advanced drug delivery.

Shakeel V, Gul I, John P, Bhatti A Saudi Pharm J. 2024; 32(6):102066.

PMID: 38726226 PMC: 11079519. DOI: 10.1016/j.jsps.2024.102066.

Evaluation of Advanced Nanomaterials for Cancer Diagnosis and Treatment.

Ndlovu N, Mdlalose W, Ntsendwana B, Moyo T Pharmaceutics. 2024; 16(4).

PMID: 38675134 PMC: 11054857. DOI: 10.3390/pharmaceutics16040473.

References

Muro-Cruces J, Roca A, Lopez-Ortega A, Fantechi E, Del-Pozo-Bueno D, Estrade S . Precise Size Control of the Growth of FeO Nanocubes over a Wide Size Range Using a Rationally Designed One-Pot Synthesis. ACS Nano. 2019; 13(7):7716-7728. DOI: 10.1021/acsnano.9b01281. View

Lee N, Choi Y, Lee Y, Park M, Moon W, Choi S . Water-dispersible ferrimagnetic iron oxide nanocubes with extremely high r₂ relaxivity for highly sensitive in vivo MRI of tumors. Nano Lett. 2012; 12(6):3127-31. DOI: 10.1021/nl3010308. View

Guardia P, Di Corato R, Lartigue L, Wilhelm C, Espinosa A, Garcia-Hernandez M . Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment. ACS Nano. 2012; 6(4):3080-91. DOI: 10.1021/nn2048137. View

Szalay B, Tatrai E, Nyiro G, Vezer T, Dura G . Potential toxic effects of iron oxide nanoparticles in in vivo and in vitro experiments. J Appl Toxicol. 2011; 32(6):446-53. DOI: 10.1002/jat.1779. View

Fortin J, Gazeau F, Wilhelm C . Intracellular heating of living cells through Néel relaxation of magnetic nanoparticles. Eur Biophys J. 2007; 37(2):223-8. DOI: 10.1007/s00249-007-0197-4. View

Park J, Baek M, Choi E, Woo S, Kim J, Kim T . Paramagnetic ultrasmall gadolinium oxide nanoparticles as advanced T1 MRI contrast agent: account for large longitudinal relaxivity, optimal particle diameter, and in vivo T1 MR images. ACS Nano. 2009; 3(11):3663-9. DOI: 10.1021/nn900761s. View

Gupta A, Naregalkar R, Vaidya V, Gupta M . Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications. Nanomedicine (Lond). 2007; 2(1):23-39. DOI: 10.2217/17435889.2.1.23. View

Feng Q, Liu Y, Huang J, Chen K, Huang J, Xiao K . Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings. Sci Rep. 2018; 8(1):2082. PMC: 5794763. DOI: 10.1038/s41598-018-19628-z. View

Kakwere H, Pernia Leal M, Materia M, Curcio A, Guardia P, Niculaes D . Functionalization of strongly interacting magnetic nanocubes with (thermo)responsive coating and their application in hyperthermia and heat-triggered drug delivery. ACS Appl Mater Interfaces. 2015; 7(19):10132-45. DOI: 10.1021/am5088117. View

10.

Issa B, Obaidat I, Albiss B, Haik Y . Magnetic nanoparticles: surface effects and properties related to biomedicine applications. Int J Mol Sci. 2013; 14(11):21266-305. PMC: 3856004. DOI: 10.3390/ijms141121266. View

11.

Shubitidze F, Kekalo K, Stigliano R, Baker I . Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy. J Appl Phys. 2015; 117(9):094302. PMC: 4352167. DOI: 10.1063/1.4907915. View

12.

Huang W, Yang F, Zhu L, Qiao R, Zhao Y . Manipulation of magnetic nanorod clusters in liquid by non-uniform alternating magnetic fields. Soft Matter. 2017; 13(20):3750-3759. DOI: 10.1039/c7sm00488e. View

13.

Bharde A, Wani A, Shouche Y, Joy P, Prasad B, Sastry M . Bacterial aerobic synthesis of nanocrystalline magnetite. J Am Chem Soc. 2005; 127(26):9326-7. DOI: 10.1021/ja0508469. View

14.

Kralj S, Makovec D . Magnetic Assembly of Superparamagnetic Iron Oxide Nanoparticle Clusters into Nanochains and Nanobundles. ACS Nano. 2015; 9(10):9700-7. DOI: 10.1021/acsnano.5b02328. View

15.

Veiseh O, Gunn J, Zhang M . Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev. 2009; 62(3):284-304. PMC: 2827645. DOI: 10.1016/j.addr.2009.11.002. View

16.

Niculaes D, Lak A, Anyfantis G, Marras S, Laslett O, Avugadda S . Asymmetric Assembling of Iron Oxide Nanocubes for Improving Magnetic Hyperthermia Performance. ACS Nano. 2017; 11(12):12121-12133. PMC: 6097834. DOI: 10.1021/acsnano.7b05182. View

17.

Kim D, Lee N, Park M, Kim B, An K, Hyeon T . Synthesis of uniform ferrimagnetic magnetite nanocubes. J Am Chem Soc. 2008; 131(2):454-5. DOI: 10.1021/ja8086906. View

18.

Revia R, Zhang M . Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances. Mater Today (Kidlington). 2016; 19(3):157-168. PMC: 4981486. DOI: 10.1016/j.mattod.2015.08.022. View

19.

Stoehr L, Gonzalez E, Stampfl A, Casals E, Duschl A, Puntes V . Shape matters: effects of silver nanospheres and wires on human alveolar epithelial cells. Part Fibre Toxicol. 2012; 8:36. PMC: 3275490. DOI: 10.1186/1743-8977-8-36. View

20.

Nath S, Kaittanis C, Ramachandran V, Dalal N, Perez J . Synthesis, magnetic characterization and sensing applications of novel dextran-coated iron oxide nanorods. Chem Mater. 2010; 21(8):1761-1767. PMC: 2830002. DOI: 10.1021/cm8031863. View