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Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with Nivolumab

Overview
Publisher MDPI
Specialty General Medicine
Date 2020 Apr 5
PMID 32244416
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Abstract

Radiation-induced sarcoma (RIS) has been reported as a late secondary malignancy following radiotherapy for various types of cancer with a median latency of 10 years. We describe an early RIS that developed in an adolescent within three years of treatment (including PD-L1 check-point inhibitor Nivolumab) of a relapsed classic Hodgkin lymphoma (HL) and was diagnosed post-mortem. The patient died of the progressive RIS that was misleadingly assumed to be a resistant HL based on the positive PET/CT scan. Repetitive tumor biopsies are warranted in cases of aggressive and multi-drug resistant HL to validate imaging findings, ensure correct diagnosis and avoid overtreatment.

References
1.
Altaf S, Enders F, Jeavons E, Krailo M, Barkauskas D, Meyers P . High-BMI at diagnosis is associated with inferior survival in patients with osteosarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2013; 60(12):2042-6. DOI: 10.1002/pbc.24580. View

2.
Hodgson D, Gilbert E, Dores G, Schonfeld S, Lynch C, Storm H . Long-term solid cancer risk among 5-year survivors of Hodgkin's lymphoma. J Clin Oncol. 2007; 25(12):1489-97. DOI: 10.1200/JCO.2006.09.0936. View

3.
Kasamon Y, De Claro R, Wang Y, Shen Y, Farrell A, Pazdur R . FDA Approval Summary: Nivolumab for the Treatment of Relapsed or Progressive Classical Hodgkin Lymphoma. Oncologist. 2017; 22(5):585-591. PMC: 5423515. DOI: 10.1634/theoncologist.2017-0004. View

4.
Walden M, Murphey M, Vidal J . Incidental enchondromas of the knee. AJR Am J Roentgenol. 2008; 190(6):1611-5. DOI: 10.2214/AJR.07.2796. View

5.
Sklar C, Whitton J, Mertens A, Stovall M, Green D, Marina N . Abnormalities of the thyroid in survivors of Hodgkin's disease: data from the Childhood Cancer Survivor Study. J Clin Endocrinol Metab. 2000; 85(9):3227-32. DOI: 10.1210/jcem.85.9.6808. View