Zika Virus Circulates at Low Levels in Western and Coastal Kenya

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2020 Apr 4

PMID 32242626

Citations 6

Authors

Theodore A Gobillot

Caroline Kikawa

Dara A Lehman

John Kinuthia

Alison L Drake

Walter Jaoko

Kishorchandra Mandaliya

Grace John-Stewart

R Scott McClelland

Julie Overbaugh

Affiliations

Soon will be listed here.

Abstract

Background: Zika virus (ZIKV) was discovered over 70 years ago in East Africa, but little is known about its circulation and pathogenesis there.

Methods: We screened 327 plasma samples collected 2-12 months after febrile illness in Western and coastal Kenya (1993-2016) for binding and neutralizing antibodies to distinguish ZIKV and dengue virus (DENV) responses, which we found were common in coastal Kenya.

Results: Two cases had durable ZIKV-specific antibodies and 2 cases had ZIKV antibodies at similar levels as DENV antibodies.

Conclusions: This suggests low-level ZIKV circulation in Kenya over 2 decades and sets a baseline for future surveillance efforts in East Africa.

Citing Articles

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Arthropod-borne diseases among travellers arriving in Europe from Africa, 2015 to 2019.

Gossner C, Hallmaier-Wacker L, Briet O, Haussig J, De Valk H, Wijermans A Euro Surveill. 2023; 28(7).

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Osoro E, Inwani I, Mugo C, Hunsperger E, Verani J, Omballa V BMC Med. 2022; 20(1):291.

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Tsuji I, Vang F, Dominguez D, Karwal L, Sanjali A, Livengood J J Virol. 2022; 96(11):e0007122.

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