Bleeding Index and Monocyte Chemoattractant Protein 1 As Gingival Inflammation Parameters After Chemical-Mechanical Retraction Procedure

Overview

Journal Med Princ Pract

Publisher Karger

Specialties General Medicine
Medical Education

Date 2020 Apr 3

PMID 32241014

Citations 4

Authors

Marko Igic

Milena Kostic

Jelena Basic

Nebojsa Krunic

Ana Pejcic

Nikola Gligorijevic

Aleksandra Milic Lemic

Affiliations

Soon will be listed here.

Abstract

Objective: A widely used chemical-mechanical method of gingival retraction can cause gingival tissue damage. The aim of this study was to test the influence of the chemical-mechanical gingival retraction procedures on the gingival bleeding index (GBI) and the salivary concentration of monocyte chemoattractant protein 1 (MCP-1) as an indicator of inflammatory changes in the gingiva.

Materials And Methods: The effects of 2 different retraction agents (aluminum chloride and ferric sulfate) were compared, particularly their tissue damaging effect during tooth preparation. Therefore, GBI values and the salivary concentration of MCP-1 were assessed during the chemical-mechanical method of gingival retraction in a homogenous group of respondents. The subjects (n = 60) were divided into 2 experimental groups (G1 and G2) regarding the need for tooth preparing and making artificial crowns. Each group was further divided into 2 subgroups (R1 and R2) according to the type of the gingival retraction agent used (aluminum chloride and ferric sulfate).

Results: Compared to the values at the study start, a statistically significant increase in GBI and salivary MCP-1 (p < 0.001) 1 day after gingival retraction agent application was observed in both experimental groups. After 72 h, the values were lower than in the second observation period but still statistically significantly higher compared to the study start (p < 0.001), which indicated the reversibility of the tissue changes.

Conclusion: Higher values of the investigated parameters were observed in the group of subjects with prepared teeth, and clinical changes were more pronounced after the use of ferric sulfate.

Citing Articles

Determination of Gingival Index and Salivary Proinflammatory Cytokines (Interleukin 6 and Tumour Necrosis Factor α) After Chemical-Mechanical Retraction Procedure.

Igic M, Kostic M, dordevic N, Basic J, dordevic M, Gligorijevic N Diagnostics (Basel). 2025; 15(4).

PMID: 40002575 PMC: 11854809. DOI: 10.3390/diagnostics15040424.

Cytomorphometric and Clinical Changes in Gingival Tissue after Subgingival Tooth Preparation-A Pilot Study.

Jovanovic M, Zivkovic N, Gligorijevic N, Igic M, Petrovic M, Bojovic M Healthcare (Basel). 2023; 11(3).

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Effects of oral administration of Bifidobacterium animalis subsp. lactis HN019 on the treatment of plaque-induced generalized gingivitis.

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Local delivery of a CXCR3 antagonist decreases the progression of bone resorption induced by LPS injection in a murine model.

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Biological Response Induced in Primary Human Gingival Fibroblasts upon Exposure to Various Types of Injectable Astringent Retraction Agents.

Nowakowska D, Kulbacka J, Wezgowiec J, Szewczyk A, Baczynska D, Zietek M Materials (Basel). 2021; 14(8).

PMID: 33924145 PMC: 8074361. DOI: 10.3390/ma14082081.

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