Extracellular Vesicles Function As Bioactive Molecular Transmitters in the Mammalian Oviduct: An Inspiration for Optimizing in Vitro Culture Systems and Improving Delivery of Exogenous Nucleic Acids During Preimplantation Embryonic Development

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Apr 3

PMID 32235756

Citations 10

Authors

Bo Fu

Hong Ma

Di Liu

Affiliations

Soon will be listed here.

Abstract

Two technologies, in vitro culture and exogenous gene introduction, constitute cornerstones of producing transgenic animals. Although in vitro embryo production techniques can bypass the oviduct during early development, such embryos are inferior to their naturally produced counterparts. In addition, preimplantation embryos are resistant to the uptake of exogenous genetic material. These factors restrict the production of transgenic animals. The discovery of extracellular vesicles (EVs) was a milestone in the study of intercellular signal communication. EVs in the oviduct, known as oviductosomes (OVS), are versatile delivery tools during maternal-embryo communication. In this review, we discuss the important roles of OVS in these interactions and the feasibility of using them as tools for transferring exogenous nucleic acids during early development. We hypothesize that further accurate characterization of OVS cargoes and functions will open new horizons for research on maternal-embryo interactions and enhance the production of transgenic animals.

Citing Articles

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References

Maas S, Breakefield X, Weaver A . Extracellular Vesicles: Unique Intercellular Delivery Vehicles. Trends Cell Biol. 2016; 27(3):172-188. PMC: 5318253. DOI: 10.1016/j.tcb.2016.11.003. View

Tsai N, Lee B, Kim A, Yang R, Pan R, Lee D . Nanomedicine for global health. J Lab Autom. 2014; 19(6):511-6. DOI: 10.1177/2211068214538263. View

Lin S, Yu Z, Chen D, Wang Z, Miao J, Li Q . Progress in Microfluidics-Based Exosome Separation and Detection Technologies for Diagnostic Applications. Small. 2019; 16(9):e1903916. DOI: 10.1002/smll.201903916. View

Chen S, Einspanier R, Schoen J . Long-term culture of primary porcine oviduct epithelial cells: validation of a comprehensive in vitro model for reproductive science. Theriogenology. 2013; 80(8):862-9. DOI: 10.1016/j.theriogenology.2013.07.011. View

Mannavola F, DOronzo S, Cives M, Stucci L, Ranieri G, Silvestris F . Extracellular Vesicles and Epigenetic Modifications Are Hallmarks of Melanoma Progression. Int J Mol Sci. 2019; 21(1). PMC: 6981648. DOI: 10.3390/ijms21010052. View

Guerin P, El Mouatassim S, Menezo Y . Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Hum Reprod Update. 2001; 7(2):175-89. DOI: 10.1093/humupd/7.2.175. View

Qu P, Zhao Y, Wang R, Zhang Y, Li L, Fan J . Extracellular vesicles derived from donor oviduct fluid improved birth rates after embryo transfer in mice. Reprod Fertil Dev. 2018; 31(2):324-332. DOI: 10.1071/RD18203. View

Lee K, Yao Y, Kwok K, Xu J, Yeung W . Early developing embryos affect the gene expression patterns in the mouse oviduct. Biochem Biophys Res Commun. 2002; 292(2):564-70. DOI: 10.1006/bbrc.2002.6676. View

Wahlgren J, Karlson T, Brisslert M, Vaziri Sani F, Telemo E, Sunnerhagen P . Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes. Nucleic Acids Res. 2012; 40(17):e130. PMC: 3458529. DOI: 10.1093/nar/gks463. View

10.

Witwer K, van Balkom B, Bruno S, Choo A, Dominici M, Gimona M . Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. J Extracell Vesicles. 2019; 8(1):1609206. PMC: 6493293. DOI: 10.1080/20013078.2019.1609206. View

11.

Zhou X, Liao W, Liao J, Liao P, Lu H . Ribosomal proteins: functions beyond the ribosome. J Mol Cell Biol. 2015; 7(2):92-104. PMC: 4481666. DOI: 10.1093/jmcb/mjv014. View

12.

Fereshteh Z, Schmidt S, Al-Dossary A, Accerbi M, Arighi C, Cowart J . Murine Oviductosomes (OVS) microRNA profiling during the estrous cycle: Delivery of OVS-borne microRNAs to sperm where miR-34c-5p localizes at the centrosome. Sci Rep. 2018; 8(1):16094. PMC: 6208369. DOI: 10.1038/s41598-018-34409-4. View

13.

Cocucci E, Racchetti G, Meldolesi J . Shedding microvesicles: artefacts no more. Trends Cell Biol. 2009; 19(2):43-51. DOI: 10.1016/j.tcb.2008.11.003. View

14.

Datta T, Rajput S, Wee G, Lee K, Folger J, Smith G . Requirement of the transcription factor USF1 in bovine oocyte and early embryonic development. Reproduction. 2014; 149(2):203-12. PMC: 4286489. DOI: 10.1530/REP-14-0445. View

15.

Hunter R . Modulation of gamete and embryonic microenvironments by oviduct glycoproteins. Mol Reprod Dev. 1994; 39(2):176-81. DOI: 10.1002/mrd.1080390209. View

16.

Guduric-Fuchs J, OConnor A, Camp B, ONeill C, Medina R, Simpson D . Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types. BMC Genomics. 2012; 13:357. PMC: 3532190. DOI: 10.1186/1471-2164-13-357. View

17.

Dizaj S, Jafari S, Khosroushahi A . A sight on the current nanoparticle-based gene delivery vectors. Nanoscale Res Lett. 2014; 9(1):252. PMC: 4046008. DOI: 10.1186/1556-276X-9-252. View

18.

Huang A, Isobe N, Yoshimura Y . Changes in localization and density of CD63-positive exosome-like substances in the hen oviduct with artificial insemination and their effect on sperm viability. Theriogenology. 2017; 101:135-143. DOI: 10.1016/j.theriogenology.2017.06.028. View

19.

Lawson C, Kovacs D, Finding E, Ulfelder E, Luis-Fuentes V . Extracellular Vesicles: Evolutionarily Conserved Mediators of Intercellular Communication. Yale J Biol Med. 2017; 90(3):481-491. PMC: 5612190. View

20.

Qu P, Qing S, Liu R, Qin H, Wang W, Qiao F . Effects of embryo-derived exosomes on the development of bovine cloned embryos. PLoS One. 2017; 12(3):e0174535. PMC: 5370134. DOI: 10.1371/journal.pone.0174535. View