BRMS1: a Multifunctional Signaling Molecule in Metastasis

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 2020 Apr 2

PMID 32232621

Citations 8

Authors

Rosalyn C Zimmermann

Danny R Welch

Affiliations

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Abstract

Despite high mortality rates, molecular understanding of metastasis remains limited. It can be regulated by both pro- and anti-metastasis genes. The metastasis suppressor, breast cancer metastasis suppressor 1 (BRMS1), has been positively correlated with patient outcomes, but molecular functions are still being characterized. BRMS1 has been implicated in focal adhesion kinase (FAK), epidermal growth factor receptor (EGFR), and NF-κB signaling pathways. We review evidence that BRMS1 regulates these vast signaling pathways through chromatin remodeling as a member of mSin3 histone deacetylase complexes.

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