Glycosylated-Chitosan Derivatives: A Systematic Review

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Apr 2

PMID 32230971

Citations 11

Authors

Pasquale Sacco

Michela Cok

Francesca Scognamiglio

Chiara Pizzolitto

Federica Vecchies

Andrea Marfoglia

Eleonora Marsich

Ivan Donati

Affiliations

Soon will be listed here.

Abstract

Chitosan derivatives, and more specifically, glycosylated derivatives, are nowadays attracting much attention within the scientific community due to the fact that this set of engineered polysaccharides finds application in different sectors, spanning from food to the biomedical field. Overcoming chitosan (physical) limitations or grafting biological relevant molecules, to mention a few, represent two cardinal strategies to modify parent biopolymer; thereby, synthetizing high added value polysaccharides. The present review is focused on the introduction of oligosaccharide side chains on the backbone of chitosan. The synthetic aspects and the effect on physical-chemical properties of such modifications are discussed. Finally, examples of potential applications in biomaterials design and drug delivery of these novel modified chitosans are disclosed.

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