Virology, Epidemiology, Pathogenesis, and Control of COVID-19

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2020 Apr 2

PMID 32230900

Citations 686

Authors

Yuefei Jin

Haiyan Yang

Wangquan Ji

Weidong Wu

Shuaiyin Chen

Weiguo Zhang

Guangcai Duan

Affiliations

Soon will be listed here.

Abstract

The outbreak of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China has been brought to global attention and declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS) in 2002~2003 and Middle East respiratory syndrome (MERS) in 2012 have accelerated our understanding of the epidemiology and pathogenesis of SARS-CoV-2 and the development of therapeutics to treat viral infection. As no specific therapeutics and vaccines are available for disease control, the epidemic of COVID-19 is posing a great threat for global public health. To provide a comprehensive summary to public health authorities and potential readers worldwide, we detail the present understanding of COVID-19 and introduce the current state of development of measures in this review.

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References

Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y . Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020; 382(13):1199-1207. PMC: 7121484. DOI: 10.1056/NEJMoa2001316. View

Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C . Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020; 8(4):420-422. PMC: 7164771. DOI: 10.1016/S2213-2600(20)30076-X. View

Li H, Wang Y, Xu J, Cao B . [Potential antiviral therapeutics for 2019 Novel Coronavirus]. Zhonghua Jie He He Hu Xi Za Zhi. 2020; 43(0):E002. DOI: 10.3760/cma.j.issn.1001-0939.2020.0002. View

Leng Z, Zhu R, Hou W, Feng Y, Yang Y, Han Q . Transplantation of ACE2 Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia. Aging Dis. 2020; 11(2):216-228. PMC: 7069465. DOI: 10.14336/AD.2020.0228. View

Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N . A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000; 87(5):E1-9. DOI: 10.1161/01.res.87.5.e1. View

Yu W, Tang G, Zhang L, Corlett R . Decoding the evolution and transmissions of the novel pneumonia coronavirus (SARS-CoV-2 / HCoV-19) using whole genomic data. Zool Res. 2020; 41(3):247-257. PMC: 7231477. DOI: 10.24272/j.issn.2095-8137.2020.022. View

Savarino A, Boelaert J, Cassone A, Majori G, Cauda R . Effects of chloroquine on viral infections: an old drug against today's diseases?. Lancet Infect Dis. 2003; 3(11):722-7. PMC: 7128816. DOI: 10.1016/s1473-3099(03)00806-5. View

Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798):270-273. PMC: 7095418. DOI: 10.1038/s41586-020-2012-7. View

Wrapp D, Wang N, Corbett K, Goldsmith J, Hsieh C, Abiona O . Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020; 367(6483):1260-1263. PMC: 7164637. DOI: 10.1126/science.abb2507. View

10.

Duan J, Yan X, Guo X, Cao W, Han W, Qi C . A human SARS-CoV neutralizing antibody against epitope on S2 protein. Biochem Biophys Res Commun. 2005; 333(1):186-93. PMC: 7092839. DOI: 10.1016/j.bbrc.2005.05.089. View

11.

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H . Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020; 395(10224):565-574. PMC: 7159086. DOI: 10.1016/S0140-6736(20)30251-8. View

12.

Wenzel R, Edmond M . Managing SARS amidst uncertainty. N Engl J Med. 2003; 348(20):1947-8. DOI: 10.1056/NEJMp030072. View

13.

Fu Y, Cheng Y, Wu Y . Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools. Virol Sin. 2020; 35(3):266-271. PMC: 7090474. DOI: 10.1007/s12250-020-00207-4. View

14.

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J . A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020; 382(8):727-733. PMC: 7092803. DOI: 10.1056/NEJMoa2001017. View

15.

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J . Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020; 323(11):1061-1069. PMC: 7042881. DOI: 10.1001/jama.2020.1585. View

16.

Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M . Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020; 30(3):269-271. PMC: 7054408. DOI: 10.1038/s41422-020-0282-0. View

17.

Li F . Structure, Function, and Evolution of Coronavirus Spike Proteins. Annu Rev Virol. 2016; 3(1):237-261. PMC: 5457962. DOI: 10.1146/annurev-virology-110615-042301. View

18.

Li W, Moore M, Vasilieva N, Sui J, Wong S, Berne M . Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003; 426(6965):450-4. PMC: 7095016. DOI: 10.1038/nature02145. View

19.

Corman V, Muth D, Niemeyer D, Drosten C . Hosts and Sources of Endemic Human Coronaviruses. Adv Virus Res. 2018; 100:163-188. PMC: 7112090. DOI: 10.1016/bs.aivir.2018.01.001. View

20.

Ding Y, Wang H, Shen H, Li Z, Geng J, Han H . The clinical pathology of severe acute respiratory syndrome (SARS): a report from China. J Pathol. 2003; 200(3):282-9. PMC: 7168017. DOI: 10.1002/path.1440. View