Recent Advances in Radiotherapy of Breast Cancer

Overview

Journal Radiat Oncol

Publisher Biomed Central

Specialties Oncology
Radiology

Date 2020 Apr 2

PMID 32228654

Citations 61

Authors

Jan Haussmann

Stefanie Corradini

Carolin Nestle-Kraemling

Edwin Bolke

Freddy Joel Djiepmo Njanang

Balint Tamaskovics

Klaus Orth

Eugen Ruckhaeberle

Tanja Fehm

Svjetlana Mohrmann

Ioannis Simiantonakis

Wilfried Budach

Christiane Matuschek

Affiliations

Soon will be listed here.

Abstract

Radiation therapy is an integral part of the multidisciplinary management of breast cancer. Regional lymph node irradiation in younger trials seems to provide superior target coverage as well as a reduction in long-term toxicity resulting in a small benefit in the overall survival rate. For partial breast irradiation there are now two large trials available which support the role of partial breast irradiation in low risk breast cancer patients. Multiple randomized trials have established that a sequentially applied dose to the tumor bed improves local control with the cost of worse cosmetic results.

Citing Articles

The Extra-Tumoral Vaccine Effects of Apoptotic Bodies in the Advancement of Cancer Treatment.

Wang Y, Liu C, Pang J, Li Z, Zhang J, Dong L Small. 2025; 21(9):e2410503.

PMID: 39871756 PMC: 11878267. DOI: 10.1002/smll.202410503.

Therapeutic applications of stem cell-derived exosomes in radiation-induced lung injury.

Li Y, He Y Cancer Cell Int. 2024; 24(1):403.

PMID: 39695650 PMC: 11656720. DOI: 10.1186/s12935-024-03595-9.

Transcription Impairment of TMEM208 by ZBTB14 Suppresses Breast cancer Radiotherapy Resistance.

Li Y, Liang L J Mammary Gland Biol Neoplasia. 2024; 29(1):20.

PMID: 39692812 PMC: 11655580. DOI: 10.1007/s10911-024-09573-1.

Dosimetric analysis of half-field-based VMAT with the deep inspiration breath-hold technique for left breast cancer patients following breast-conserving surgery.

Wu W, Yin H, Liu Z, Liu L, Xiao C, Xiao Y Front Oncol. 2024; 14:1418723.

PMID: 39640275 PMC: 11617583. DOI: 10.3389/fonc.2024.1418723.

Impact of deep inspiration breath hold, surface-guided radiotherapy, and daily CBCT on the organs at risk in breast cancer radiotherapy.

Rudat V, Zhao R, Wang B, Zhang L, Shi Y Sci Rep. 2024; 14(1):27814.

PMID: 39537683 PMC: 11561235. DOI: 10.1038/s41598-024-77482-8.

References

Giuliano A, Ballman K, McCall L, Beitsch P, Brennan M, Kelemen P . Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial. JAMA. 2017; 318(10):918-926. PMC: 5672806. DOI: 10.1001/jama.2017.11470. View

Borm K, Oechsner M, Combs S, Duma M . Deep-Inspiration Breath-Hold Radiation Therapy in Breast Cancer: A Word of Caution on the Dose to the Axillary Lymph Node Levels. Int J Radiat Oncol Biol Phys. 2017; 100(1):263-269. DOI: 10.1016/j.ijrobp.2017.09.026. View

Polgar C, Fodor J, Major T, Sulyok Z, Kasler M . Breast-conserving therapy with partial or whole breast irradiation: ten-year results of the Budapest randomized trial. Radiother Oncol. 2013; 108(2):197-202. DOI: 10.1016/j.radonc.2013.05.008. View

Savolt A, Peley G, Polgar C, Udvarhelyi N, Rubovszky G, Kovacs E . Eight-year follow up result of the OTOASOR trial: The Optimal Treatment Of the Axilla - Surgery Or Radiotherapy after positive sentinel lymph node biopsy in early-stage breast cancer: A randomized, single centre, phase III, non-inferiority trial. Eur J Surg Oncol. 2017; 43(4):672-679. DOI: 10.1016/j.ejso.2016.12.011. View

Whelan T, Julian J, Berrang T, Kim D, Germain I, Nichol A . External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial. Lancet. 2019; 394(10215):2165-2172. DOI: 10.1016/S0140-6736(19)32515-2. View

Pazos M, Fiorentino A, Gaasch A, Schonecker S, Reitz D, Heinz C . Dose variability in different lymph node levels during locoregional breast cancer irradiation: the impact of deep-inspiration breath hold. Strahlenther Onkol. 2018; 195(1):13-20. DOI: 10.1007/s00066-018-1350-y. View

Romestaing P, Lehingue Y, Carrie C, Coquard R, Montbarbon X, Ardiet J . Role of a 10-Gy boost in the conservative treatment of early breast cancer: results of a randomized clinical trial in Lyon, France. J Clin Oncol. 1997; 15(3):963-8. DOI: 10.1200/JCO.1997.15.3.963. View

Haviland J, Mannino M, Griffin C, Porta N, Sydenham M, Bliss J . Late normal tissue effects in the arm and shoulder following lymphatic radiotherapy: Results from the UK START (Standardisation of Breast Radiotherapy) trials. Radiother Oncol. 2017; 126(1):155-162. PMC: 5807031. DOI: 10.1016/j.radonc.2017.10.033. View

Latty D, Stuart K, Wang W, Ahern V . Review of deep inspiration breath-hold techniques for the treatment of breast cancer. J Med Radiat Sci. 2015; 62(1):74-81. PMC: 4364809. DOI: 10.1002/jmrs.96. View

10.

Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C . Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol. 2013; 14(13):1269-77. DOI: 10.1016/S1470-2045(13)70497-2. View

11.

Matuschek C, Nestle-Kraemling C, Haussmann J, Bolke E, Wollandt S, Speer V . Long-term cosmetic outcome after preoperative radio-/chemotherapy in locally advanced breast cancer patients. Strahlenther Onkol. 2019; 195(7):615-628. DOI: 10.1007/s00066-019-01473-2. View

12.

Corradini S, Ballhausen H, Weingandt H, Freislederer P, Schonecker S, Niyazi M . Left-sided breast cancer and risks of secondary lung cancer and ischemic heart disease : Effects of modern radiotherapy techniques. Strahlenther Onkol. 2017; 194(3):196-205. DOI: 10.1007/s00066-017-1213-y. View

13.

Pazos M, Schonecker S, Reitz D, Rogowski P, Niyazi M, Alongi F . Recent Developments in Radiation Oncology: An Overview of Individualised Treatment Strategies in Breast Cancer. Breast Care (Basel). 2018; 13(4):285-291. PMC: 6170912. DOI: 10.1159/000488189. View

14.

Finazzi T, Nguyen V, Zimmermann F, Papachristofilou A . Impact of patient and treatment characteristics on heart and lung dose in adjuvant radiotherapy for left-sided breast cancer. Radiat Oncol. 2019; 14(1):153. PMC: 6714299. DOI: 10.1186/s13014-019-1364-3. View

15.

Polgar C, Fodor J, Orosz Z, Major T, Takacsi-Nagy Z, Mangel L . Electron and high-dose-rate brachytherapy boost in the conservative treatment of stage I-II breast cancer first results of the randomized Budapest boost trial. Strahlenther Onkol. 2002; 178(11):615-23. DOI: 10.1007/s00066-002-1053-1. View

16.

Hickey B, James M, Lehman M, Hider P, Jeffery M, Francis D . Fraction size in radiation therapy for breast conservation in early breast cancer. Cochrane Database Syst Rev. 2016; 7:CD003860. PMC: 6457862. DOI: 10.1002/14651858.CD003860.pub4. View

17.

Simonetto C, Eidemuller M, Gaasch A, Pazos M, Schonecker S, Reitz D . Does deep inspiration breath-hold prolong life? Individual risk estimates of ischaemic heart disease after breast cancer radiotherapy. Radiother Oncol. 2018; 131:202-207. DOI: 10.1016/j.radonc.2018.07.024. View

18.

De Rose F, Fogliata A, Franceschini D, Cozzi S, Iftode C, Stravato A . Postmastectomy radiation therapy using VMAT technique for breast cancer patients with expander reconstruction. Med Oncol. 2019; 36(6):48. DOI: 10.1007/s12032-019-1275-z. View

19.

Corradini S, Krug D, Meattini I, Matuschek C, Bolke E, Francolini G . Preoperative radiotherapy: A paradigm shift in the treatment of breast cancer? A review of literature. Crit Rev Oncol Hematol. 2019; 141:102-111. DOI: 10.1016/j.critrevonc.2019.06.003. View

20.

Jagsi R, Chadha M, Moni J, Ballman K, Laurie F, Buchholz T . Radiation field design in the ACOSOG Z0011 (Alliance) Trial. J Clin Oncol. 2014; 32(32):3600-6. PMC: 4220042. DOI: 10.1200/JCO.2014.56.5838. View